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The International Society on Oxygen Transport to Tissue (ISOTT) was founded in 1973 "to facilitate the exchange of scientific information among those interested in any aspect of the transport and/or utilization of oxygen in tissues". Its members span virtually all disciplines, extending from various branches of clinical medicine such as anesthesiology, ophthalmology and surgery through the basic medical sciences of physiology and'biochemistry to most branches of the physical sciences and engineering. The seventeenth annual meeting of ISOTT was held in 1989 for four days, from July 21 to 24, at the Max Planck Institute for Experimental Medicine and the adjoining University Hospital (Klinikum), in Goettingen, Federal Republic of Germany. It attracted 147 active registrants and approximately 40 accompanying persons. The very successful format originated by Dr. Ian Longmuir in 1985, consisting of posters accompanied by an abbreviated oral summary, was continued with slight modification. Virtually all of the presentations utilized this format, with each poster session preceded by a formal discussion during which the presenter briefly reviewed the poster aided by a few slides. All posters remained in place for the entire four days of the meeting.
The International Society on Oxygen Transport to Tissue (ISOTT) was founded in 1973 "to facilitate the exchange of scientific information among those interested in any aspect of the transport and/or utilization of oxygen in tissues". Its members span virtually all disciplines, extending from various branches of clinical medicine such as anesthesiology, ophthalmology and surgery through the basic medical sciences of physiology and'biochemistry to most branches of the physical sciences and engineering. The seventeenth annual meeting of ISOTT was held in 1989 for four days, from July 21 to 24, at the Max Planck Institute for Experimental Medicine and the adjoining University Hospital (Klinikum), in Goettingen, Federal Republic of Germany. It attracted 147 active registrants and approximately 40 accompanying persons. The very successful format originated by Dr. Ian Longmuir in 1985, consisting of posters accompanied by an abbreviated oral summary, was continued with slight modification. Virtually all of the presentations utilized this format, with each poster session preceded by a formal discussion during which the presenter briefly reviewed the poster aided by a few slides. All posters remained in place for the entire four days of the meeting.
This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 46th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2018) held in Seoul, Republic of Korea, from July 1 to July 5, 2018. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
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Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.