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This book is unique in focusing expressly on regenerative medicine in the aesthetic field. With the aid of more than 400 color pictures, it provides step-by-step descriptions of procedures that can be performed easily in the private practice. The number of people pursuing anti-aging and cosmetic procedures in order to achieve a youthful, healthy, or simply improved aspect is continually increasing. At the same time the available techniques and materials have undergone rapid innovation in terms of both safety and quality. The practitioner no longer looks just at the correction or camouflage of an unwanted feature but rather also aims to address the aging process itself. Regenerative medicine appears to provide a unique and unlimited opportunity in this context. Autologous fat grafting, adipose-derived stem cells, and autologous platelet-rich plasma represent just some of the attractive options that can be used for volume restoration and facial rejuvenation.
Regenerative medicine offers physicians new tools to help repair damaged tissue, alleviate pain, accelerate healing, and improve function for patients with degenerative conditions or sports injuries. Regenerative Treatments in Sports and Orthopedic Medicine is the first comprehensive book devoted to orthobiologic treatments for orthopedic conditions. Authored by experts in regenerative medicine, this evidence- and experience-based guide is written for clinicians looking to understand and effectively implement these treatments in their practices. Broad yet focused coverage of the scientific underpinnings, regulatory issues, staffing and equipment, nutritional and rehabilitation concerns, and orthobiologic interventions for specific clinical problems make this the ideal procedural reference for anyone working to restore function to athletes or other patients with musculoskeletal pathologies. Key Features Unparallelled coverage of clinical science and practical applications Written by pioneering leaders at the forefront of an emerging standard of care Evidence-based indications for initiating orthobiologic therapies Includes a review of important nomenclature for the novice Covers both Platelet Rich Plasma (PRP) and stem cell procedures A must-read guide for practitioners in academic and private practice settings
The 150+ year lifespan of our ancient ancestors can be achieved once again by harnessing the power of our own cells with The Stem Cell Cure! Renowned regenerative and restorative sports medicine doctor Gaurav Goswami, M.D. provides advanced minimally invasive, non-surgical treatments to help his patients get back to peak performance levels – no matter their age. Harnessing the transformative power of stem cells is central to his expertise. In fact, stem cell therapy is proven to be effective in the treatment of many common conditions from arthritis and back pain to Alzheimer’s, Parkinson’s, and cancer. This book is an accessible and informative introduction to the amazing powers of Stem Cell Therapy – the biggest revolution in medicine since the discovery of penicillin, and a wave of the future. Co-authored by bestselling author and popular keynote speaker Kerry Johnson MBA PhD, The Stem Cell Cure provides specific ways for readers to boost their health and vitality for a lifetime by recovering, regenerating, and repairing injuries and disease.
Clear, concise description of more than 100 US-guided injections in musculoskeletal medicine. Atlas of Ultrasound-Guided Musculoskeletal Injections includes numerous tips and tricks from the field's most experienced and respected practitioners. This unique and state-of–the-art text is ideal for physiatrists, rheumatologists, sports medicine physicians, radiologists, pain medicine specialists, and orthopedic surgeons. With a focus on safety and efficacy, this atlas is a worthwhile investment for any practitioner looking to add ultrasound-guided procedures to their practice or is looking to sharpen their skills. The book opens with informative coverage of the fundamentals of MSK US, including ultrasound physics, preparation and set-up for MSK US procedures, and the rationale and evidence for performing these procedures. The main body of the book dedicates one chapter to a specific US-guided injection or procedure. Each chapter design includes sections on key points, pertinent anatomy, common pathology, US imaging, indications, and technique. The book is divided into 8 sections: Shoulder Elbow Hand and wrist Pelvis Knee Foot and ankle Special procedures (rotator cuff, Percutaneous Trigger finger release, Ultrasound-guided Carpal Tunnel release, and Tenex) Atlas of Ultrasound-Guided Musculoskeletal Injections includes coverage of the full spectrum of procedures, ranging from basic US guided joint injections to perinerual injections, tenotomies, and surgical procedures such as percutaneous A1 pulley release, making the book the field's first true cornerstone text and the "go to" resource for any clinician interested in the subject.
Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. - Highly Commended 2013 BMA Medical Book Award for Medicine - Includes coverage of skin, hair, teeth, cornea, and central neural tissues - Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems - Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals
This book sheds new light on the complex area of regenerative injections used in sports injuries and musculoskeletal conditions, pursuing an evidenced-based approach. Largely ignoring orthopedic surgery, which would involve arthroscopic procedures and scaffolding as they are practiced mainly by orthopedic surgeons, the book instead focuses on injection-based treatments that are particularly useful in sports medicine and for musculoskeletal pain conditions. Including evidence from systematic reviews, meta-analyses, and randomized controlled trials, the book provides a comprehensive overview of regenerative injections such as dextrose, platelet-rich plasma and stem cell therapy, along with their history and scientific basis. It also includes detailed information on the preparation methods, steps of the procedure, and clinical conditions most likely to benefit from it. Given its scope, the book offers a valuable tool for all medical practitioners whose work involves painful musculoskeletal conditions, e.g. sports medicine physicians, orthopedists and interventional physiatrists, as well as general practitioners.
Over the recent years, biotechnology has become responsible for explaining interactions of biological tools and processes so that many scientists in the life sciences from agronomy to medicine are engaged in biotechnological research. This book contains an overview focusing on the research area of molecular biology, molecular aspects of biotechnology, synthetic biology and agricultural applications in relevant approaches. The book deals with basic issues and some of the recent developments in biotechnological applications. Particular emphasis is devoted to both theoretical and experimental aspect of modern biotechnology. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in associated areas. The book is written by international scientists with expertise in chemistry, protein biochemistry, enzymology, molecular biology and genetics, many of which are active in biochemical and biomedical research. We hope that the book will enhance the knowledge of scientists in the complexities of some biotechnological approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications.
Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.