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How Did Life Begin? There are two scientific views on the origins of life: 1) Earthly-Abiogenesis which argues life on Earth began on Earth, and 2) Extraterrestrial Abiogenesis the position of which is life has an ancestry which predates the origins of Earth, and is pervasive throughout the cosmos. Thus, both theories embrace abiogenesis" and both argue that life may have begun on innumerable planets via the same mechanisms. In this ground-breaking, revolutionary text, over 30 top scientists from around the world, explain how life began and if there is life on other worlds, in over 20 paradigm busting chapters. PART I: Earthly Abiogenesis & the Origins of Life 1. Why Does Life Start, What Does It Do, Where Will It Be, And How Might We Find It? Michael J. Russell, Ph.D., and Isik Kanik, Ph.D., 2. Just Like the Universe the Emergence of Life had High Enthalpy and Low Entropy Beginnings, Wolfgang Nitschke, Ph.D., and Michael J. Russell, Ph.D. 3. Polyphosphate-Peptide Synergy and the Organic Takeover at the Emergence of Life. E. James Milner-White, Ph.D., and Michael J. Russell, Ph.D. 4. The Alkaline World and the Origin of Life. Anthony Richard Mellersh, Ph.D., and Paul Michael Smith, 5. Amino Acid Homochirality and the RNA World: Necessities for Life on Earth, Koji Tamura, Ph.D., 6. The RNA World and the Origin of Life: An Ancient Protein Fold Links Metal-Based Gas Reactions with the RNA World. Anne Volbeda, Ph.D., Yvain Nicolet, Ph.D., and Juan C. Fontecilla-Camps, Ph.D. 7. Evolutionary Steps to the Origin of Life on Earth. Andrew J. Pratt, D. Phil. 8. Vesicles First and the Origin of Self-Reproductive Life: Metabolic Energy, Replication, and Catalysis. Arthur L. Koch, Ph.D., 9. Chance or Necessity? Bioenergetics and the Probability of Life. Nick Lane, Ph.D. 10. Disequilibrium First: The Origin of Life Christof B. Mast, Ph.D., Natan Osterman, Ph.D., and Dieter Braun, Ph.D. 11. Life's Origins: Potential for Radical Mediated Cyanide Production on the Early Earth, Shawn E. McGlynn, Ph.D., Trevor E. Beard, Joan B. Broderick, Ph.D., and John W. Peters, Ph.D. 12. The Emergence of Life: Thermodynamics of Chemical Free Energy Generation in Off-Axis Hydrothermal Vent Systems & Consequences for Compartmentalization & Life's Origins. Eugenio Simoncini, Ph.D., Axel Kleidon, Ph.D., Enzo Gallori, Ph.D. 13. How Life Began: The Emergence of Sparse Metabolic Networks, Shelley D. Copley, Ph.D., Eric Smith, Ph.D., and Harold J. Morowitz, Ph.D., 14. Redox Homeostasis in the Emergence of Life. On the Constant Internal Environment of Nascent Living Cells, John F. Allen, Ph.D. 15. Reconstruction of the Molecular Origin of Life. Edward N. Trifonov, Ph.D., 16. How Primordial Cells Assembled Biosynthetic Pathways, Marco Fondi, Ph.D., Giovanni Emiliani, Ph.D., Renato Fani, Ph.D., 17. On the Emergence of Pre-Genetic Information. Ernesto Di Mauro, Ph.D., 18. Implications For An RNA-Clay World: Interaction Of Cytosine With Clay Minerals, A. Pucci, Ph.D., et al. 19. Viruses and Life: Can There Be One Without the Other? Matti Jalasvuori, Ph.D., and Jaana K.H. Bamford, Ph.D., 20. The Origin of Eukaryotes: Archae, Bacteria, Viruses and Horizontal Gene Transfer, R. Joseph, Ph.D. 21. What Can the Origin of Life on Earth Tell Us About the Cosmos? Stephen Freeland, Ph.D., and Gayle K. Philip, Ph.D. PART II: Extra-Terrestrial Abiogenesis 22. 1. Biological Cosmology and the Origins of Life in the Universe, R. Joseph, Ph.D., Rudolf Schild, Ph.D 23. First Life in the Oceans of Primordial-Planets: The Biological Big Bang. C.H. Gibson, Ph.D., N.C. Wickramasinghe, Ph.D., R.E. Schild, Ph.D 24. Genetics Indicates Extra-Terrestrial Origins of Life: the First Gene. R. Joseph, Ph.D., Rudolf Schild, Ph.D., N.C. Wickramasinghe, Ph.D.,
What is the origin of life? How did life begin? The question of life's origins has been asked for thousands of years and a variety of theories have been proposed. Yet, perhaps the right question has never been asked, which is, what does life do? To understand life, we must understand what it is, what it does, how it evolved from simple chemicals to self-replicating molecule, and then the questions of origins can be properly addressed. Did life begin in a deep sea thermal vent, or in an alkaline world? What were the role of viruses in kick starting life? Did life emerge from disequilibrium? What is the source of pre-genetic information? Did vesicles come first, or only after life had begun? In this text, over 20 of the world's leading scientists ask, and answer the hard questions, and in so doing may have ushered in a paradigm shift, and a scientific revolution in our understanding of the nature of life and its origins.
Seventy years ago, Erwin Schrödinger posed a profound question: 'What is life, and how did it emerge from non-life?' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged. This new edition includes an Epilogue describing developments in the concepts of fundamental forms of stability discussed in the book, and their profound implications. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.
All life starts as stardust and all life requires packaging for molecules, proteins, DNA, and other crucial bits. Introducing astrobiology, this book presents a provocative hypothesis for the environmental conditions and raw materials needed for life to begin and evolve on earth.
A rigorous and scientific analysis of the myriad possibilities of life beyond our planet. ÒAre we alone in the universe?Ó This tantalizing question has captivated humanity over millennia, but seldom has it been approached rigorously. Today the search for signatures of extraterrestrial life and intelligence has become a rapidly advancing scientific endeavor. Missions to Mars, Europa, and Titan seek evidence of life. Laboratory experiments have made great strides in creating synthetic life, deepening our understanding of conditions that give rise to living entities. And on the horizon are sophisticated telescopes to detect and characterize exoplanets most likely to harbor life. Life in the Cosmos offers a thorough overview of the burgeoning field of astrobiology, including the salient methods and paradigms involved in the search for extraterrestrial life and intelligence. Manasvi Lingam and Abraham Loeb tackle three areas of interest in hunting for life Òout thereÓ: first, the pathways by which life originates and evolves; second, planetary and stellar factors that affect the habitability of worlds, with an eye on the biomarkers that may reveal the presence of microbial life; and finally, the detection of technological signals that could be indicative of intelligence. Drawing on empirical data from observations and experiments, as well as the latest theoretical and computational developments, the authors make a compelling scientific case for the search for life beyond what we can currently see. Meticulous and comprehensive, Life in the Cosmos is a master class from top researchers in astrobiology, suggesting that the answer to our age-old question is closer than ever before.
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Living material contains about twenty different sorts of atom combined into a set of relatively simple molecules. Astrobiologists tend to believe that abiotic mater ial will give rise to life in any place where these molecules exist in appreciable abundances and where physical conditions approximate to those occurring here on Earth. We think this popular view is wrong, for it is not the existence of the building blocks of life that is crucial but the exceedingly complicated structures in which they are arranged in living forms. The probability of arriving at biologically significant arrangements is so very small that only by calling on the resources of the whole universe does there seem to be any possibility of life originating, a conclusion that requires life on the Earth to be a minute component of a universal system. Some think that the hugely improbable transition from non-living to living mat ter can be achieved by dividing the transition into many small steps, calling on a so-called 'evolutionary' process to bridge the small steps one by one. This claim turns on semantic arguments which seek to replace the probability for the whole chain by the sum of the individual probabilities of the many steps, instead of by their product. This is an error well known to those bookies who are accustomed to taking bets on the stacking of horse races. But we did not begin our investigation from this point of view.
The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.
Uniting the foundations of physics and biology, this groundbreaking multidisciplinary and integrative book explores life as a planetary process.
This book surveys the models for the origin of life and presents a new model starting with shaped droplets and ending with life as polygonal Archaea; it collects the most published micrographs of Archaea (discovered only in 1977), which support this conclusion, and thus provides the first visual survey of Archaea. Origin of Life via Archaea’s purpose is to add a new hypothesis on what are called “shaped droplets”, as the starting point, for flat, polygonal Archaea, supporting the Vesicles First hypothesis. The book contains over 6000 distinct references and micrographs of 440 extant species of Archaea, 41% of which exhibit polygonal phenotypes. It surveys the intellectual battleground of the many ideas of the origin of life on earth, chemical equilibrium, autocatalysis, and biotic polymers. This book contains 17 chapters, some coauthored, on a wide range of topics on the origin of life, including Archaea’s origin, patterns, and species. It shows how various aspects of the origin of life may have occurred at chemical equilibrium, not requiring an energy source, contrary to the general assumption. For the reader’s value, its compendium of Archaea micrographs might also serve many other interesting questions about Archaea. One chapter presents a theory for the shape of flat, polygonal Archaea in terms of the energetics at the surface, edges and corners of the S-layer. Another shows how membrane peptides may have originated. The book also includes a large table of most extant Archaea, that is searchable in the electronic version. It ends with a chapter on problems needing further research. Audience This book will be used by astrobiologists, origin of life biologists, physicists of small systems, geologists, biochemists, theoretical and vesicle chemists.