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Alistair D'Arcy McDermott has a great mum and a great dad who love him very much ... but aren't so keen on each other. He also has a best friend with a wicked laugh and a teacher who wears tight white trousers and likes humiliating kids. So when his mum decides that she's going on a blind date with the teacher from hell, Burke the Jerk, Al's worst nightmare has come true. And when she tells him that they're going on holiday with her new man, Al's got to do something drastic. He packs his bag of total destruction and heads off for the holiday of a lifetime ...
Alastair D'Arcy McDermott - otherwise known as Al - is less than thrilled at his holiday project: helping out at the local old people's home. How did he end up getting stuck with old Violet Rose and batty Major Maddocks? But then he meets the sinister Mrs Black, and the fun begins - Al's on his greatest mission yet ... And don't miss the first story of Al's adventures, OPERATION ITCHY BUM.
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Boyface Antelope has been waiting his whole life to turn ten and be allowed to enter his parents' stripemongering shop so he can take stripes off animals and put them on something different. Like tartan onto badgers, or removing the stripes of zebras to make ponies. On the morning of his tenth birthday he finds his parents ill, and they ask him not just to go in the shop but to look after it on his own! Will he be able to keep the stripemongery running smoothly?
Join Secret Agent Barker on his crazy quest to rid the world of megafleas. Lift the flaps, fold out pages. Humorous. 4 yrs+
Aunt Edna has created a no-nonsense nanny android to make sure Billy and Alfie don't have any fun. But then Alfie discovers how to override Auntie Anne-Droid's programming and nothing can stop them eating all the Cheeki Choko Cherry Cakes they like ... until the real aunt Edna is kidnapped!
The second book in the brilliant Roald Dahl Funny Prize winning BARRY LOSER series. Perfect for readers aged 7-10 years old and fans of Diary of a Wimpy Kid, Tom Gates and Dennis the Menace. You know when someone's horrible to you in a dream and you wake up really annoyed with them? That's what happened to me with my best friend Bunky. Barry has a new problem: Gordon Smugly - who's got the most perfect name for himself ever in the history of having a name, because he looks like a Gordon and is smug and ugly - has stolen Barry's best friend. Join Barry as he attempts to get Bunky back, organises a girly-screamvoice test and tries to avoid seeing his teacher kissing his gran. Have you got all of Jim Smith’s amazekeel books? I am not a Loser I am still not a Loser I am so over being a Loser I am sort of a Loser Barry Loser and the holiday of doom Barry Loser and the case of the crumpled carton Barry Loser’s ultimate book of keelness Barry Loser hates half term My mum is a loser My dad is a loser Future Ratboy and the attack of the killer robot grannies Future Ratboy and the invasion of the nom noms Future Ratboy and the quest for the missing thingy Barry Loser: I am Not a Loser was selected as a Tom Fletcher Book Club 2017 title. Jim Smith is the keelest kids’ book author in the whole wide world amen. He graduated from art school with first class honours (the best you can get) and went on to create the branding for a sweet little chain of coffee shops. He also designs cards and gifts under the name Waldo Pancake.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
The second edition of Surgical Treatment of Hemorrhoids covers this important and common disorder, offering a comprehensive critical analysis of advantages and disadvantages of recognized treatment options, covering both recent advances and traditional treatments in the field. The topics covered include essential elements of diagnosis, surgical technique and after-care for the main operations used in hemorrhoid surgery. Providing authoritative in-depth presentations of all perspectives and latest techniques available, the individual procedures are each described by an internationally recognized expert, and the full range of treatment options is covered. The chapters have been revised, with some additions and updates, including stapled hemorrhoidectomy and office management, and also hemorrhoidectomy with several concomitant comorbidities. This uniquely comprehensive guide is essential reading for all practicing and trainee colorectal and general surgeons.