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Alistair D'Arcy McDermott has a great mum and a great dad who love him very much ... but aren't so keen on each other. He also has a best friend with a wicked laugh and a teacher who wears tight white trousers and likes humiliating kids. So when his mum decides that she's going on a blind date with the teacher from hell, Burke the Jerk, Al's worst nightmare has come true. And when she tells him that they're going on holiday with her new man, Al's got to do something drastic. He packs his bag of total destruction and heads off for the holiday of a lifetime ...
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Updated annually with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor uses the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on more than 900 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all updated by experts in key clinical fields. Updated algorithms and current clinical practice guidelines help you keep pace with the speed of modern medicine. Contains significant updates throughout, with more than 500 new figures, tables, and boxes added to this new edition. Features 17 all-new topics including opioid overdose, obesity-Hypoventilation syndrome, acute pelvic pain in women, new-onset seizures, and eosinophilic esophagitis, among many others. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Includes cross-references, outlines, bullets, tables, boxes, and algorithms to help you navigate a wealth of clinical information. Offers access to exclusive online content: more than 90 additional topics; new algorithms, images, and tables; EBM boxes; patient teaching guides, color images, and more.
Boyface Antelope has been waiting his whole life to turn ten and be allowed to enter his parents' stripemongering shop so he can take stripes off animals and put them on something different. Like tartan onto badgers, or removing the stripes of zebras to make ponies. On the morning of his tenth birthday he finds his parents ill, and they ask him not just to go in the shop but to look after it on his own! Will he be able to keep the stripemongery running smoothly?
They left the dome in ashes. The last survivors of The Eden Project had to leave the cursed planet behind venturing out beyond the reaches of the solar system into trillions of miles of uncharted space. They drift silently across the never-ending night hoping to one day reach the next star system and begin their hunt for New Earth. Days they keep busy maintaining life support systems. Nights they struggle to sleep. It’s always night in space and when their eyes are closed, the beasts can still hunt them. When Gen awakens from months in deep sleep, she discovers that they are not alone out there in the dark and nightmares are far more terrifying when your eyes are open.
Albeit a very common symptom in dermatology, internal medicine, psychosomatics, neurology, and even oncology, itching was under-researched up until 15 years ago. Since then, the clinical aspects of acute and chronic itch have been examined extensively. As a result, some books on the topic have become available. Whereas most publications focus on experimental aspects and diagnostics, this volume of the series 'Current Problems in Dermatology' provides a comprehensive overview regarding the management of chronic itch. Select authors consider interdisciplinary aspects as well as age, body region, and specific diseases as they present a great variety of available treatments. All physicians with patients suffering from itch – especially dermatologists, general practitioners, gerontologists, nephrologists, hepatologists, neurologists, and palliative care doctors – will find this publication to be an essential source of information.
In the eighteenth century, the Western world viewed circumcision as an embarrassing disfigurement peculiar to Jews. A century later, British doctors urged parents to circumcise their sons as a routine precaution against every imaginable sexual dysfunction, from syphilis and phimosis to masturbation and bed-wetting. Thirty years later the procedure again came under hostile scrutiny, culminating in its disappearance during the 1960s. Why Britain adopted a practice it had traditionally abhorred and then abandoned it after only two generations is the subject of A Surgical Temptation. Robert Darby reveals that circumcision has always been related to the question of how to control male sexuality. This study explores the process by which the male genitals, and the foreskin especially, were pathologized, while offering glimpses into the lives of such figures as James Boswell, John Maynard Keynes, and W. H. Auden. Examining the development of knowledge about genital anatomy, concepts of health, sexual morality, the rise of the medical profession, and the nature of disease, Darby shows how these factors transformed attitudes toward the male body and its management and played a vital role in the emergence of modern medicine.
An expert shows how to cultivate "aha" moments—flashes of insight—that lead to business innovation and personal success. Insight: Encouraging Aha! Moments for Organizational Success helps individuals and organizations create the conditions that lay the groundwork for the distinct "Aha!" instances of insight—when connections between different pieces of information are revealed and ideas come together in ways that have never existed before. Insight examines three stages of the Aha! experience, from the early confusion and chaos of "too much information," to how people organize and try out what they learn, to the "Aha!" moment itself. It then examines techniques people use to spark the creative aha experience—techniques that will work in a private business, education, government, nonprofit, and any other organizational setting. The book is based on interviews with over 100 people of all ages, backgrounds, and professions—from software developers to dancers, from detectives to football coaches—as well as the latest research results from management, psychology, and neuroscience studies about the workings of the brain in creative situations.