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Gamma ray detection techniques for radioisotope imaging purposes are quickly evolving. Monte Carlo simulations show the possibility of achieving an outstanding image spatial resolution in the images obtained with techniques using electronic collimation. The great advantage of using electronic collimation is the increased efficiency of the gamma camera with respect to the usage of the mechanical collimation technique. These new imaging techniques require radiation detectors with very specific features, such as low noise, desired stooping power and compactness. In this thesis project, an apparatus for detection of a Compton deposition of gamma rays, capable of differentiating the position of interaction of the gamma ray in the active volume of the detector, has been developed. The design and manufacture of such an apparatus implies the selection and characterization of the radiation sensitive material and its calibration, as well as its associated electronics, in order to achieve the critical requirements to be used as part of the electronic collimated gamma camera. Along with the detector development, the electronic collimation requires a very specific control system. The required logic system that makes possible the usage of the apparatus as part of the the electronic collimation set-up, has also been developed as part of this thesis work. This electronic system is meant to work in coordination with other sensors, and its final output is to give exact information of the photon-electron interaction points, in order for an image to be deduced. The result of this thesis work is a radiation detector ready to be used as the tracker component in the application of the electronic collimation technique. Its control system allows it to be used to build a Compton camera by simply removing the mechanical collimator of a regular gamma-camera, and arranging both detectors in the desired radioisotope imaging electronic collimation scenario.
This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Integrating aspects of engineering, application physics, and medical science, Solid-State Radiation Detectors: Technology and Applications offers a comprehensive review of new and emerging solid-state materials-based technologies for radiation detection. Each chapter is structured to address the current advantages and challenges of each material and technology presented, as well as to discuss novel research and applications. Featuring contributions from leading experts in industry and academia, this authoritative text: Covers modern semiconductors used for radiation monitoring Examines CdZnTe and CdTe technology for imaging applications including three-dimensional capability detectors Highlights interconnect technology for current pixel detectors Describes hybrid pixel detectors and their characterizations Tackles the integrated analog signal processing read-out front ends for particle detectors Considers new organic materials with direct bandgap for direct energy detection Summarizes recent developments involving lanthanum halide and cerium bromide scintillators Analyzes the potential of recent progress in the field of crystallogenesis, quantum dots, and photonics crystals toward a new concept of x- and gamma-ray detectors based on metamaterials Explores position-sensitivity photomultipliers and silicon photomultipliers for scintillation crystals Solid-State Radiation Detectors: Technology and Applications provides a valuable reference for engineers and scientists looking to enhance the performance of radiation detector technology for medical imaging and other applications.
Nuclear medicine has become an ever-changing and expanding diagnostic and therapeutic medical profession. The day-to-day innovations seen in the field are, in great part, due to the integration of many scientific bases with complex technologic advances. The aim of this reference book, Basic Sciences of Nuclear Medicine, is to provide the reader with a comprehensive and detailed discussion of the scientific bases of nuclear medicine, covering the different topics and concepts that underlie many of the investigations and procedures performed in the field. Topics include radiation and nuclear physics, Tc-99m chemistry, single-photon radiopharmaceuticals and PET chemistry, radiobiology and radiation dosimetry, image processing, image reconstruction, quantitative SPECT imaging, quantitative cardiac SPECT, small animal imaging (including multimodality hybrid imaging, e.g., PET/CT, SPECT/CT, and PET/MRI), compartmental modeling, and tracer kinetics.
Focusing on resource awareness in field-programmable gate array (FPGA) design, Applications of Field-Programmable Gate Arrays in Scientific Research covers the principle of FPGAs and their functionality. It explores a host of applications, ranging from small one-chip laboratory systems to large-scale applications in "big science." The book first de
Stroke represents a clinical syndrome of rapid onset of focal or sometimes global cerebral deficit with a vascular cause, lasting more than 24 hours or leading to death. Eighty per cent of all strokes are ischaemic, 15% are due to intracerebral haemorrhage, and 5% to subarachnoid haemorrhage. Correct diagnosis is important because treatment options for ischemic stroke may be contraindicated in case of intracerebral haemorrhage. Such exact diagnosis requires state-of-the-art imaging of the brain. But which kind of imaging, how quickly should it be done, should this include imaging of cerebral blood flow, and what is the most cost effective approach? Answering these questions may help to further narrow the gap between experimental and clinical research as well may substantially improve the patient's care.
Despite the often difficult and time-consuming effort of performing experiments with fast (14 MeV) neutrons, these neutrons can offer special insight into nucleus and other materials because of the absence of charge. 14 MeV Neutrons: Physics and Applications explores fast neutrons in basic science and applications to problems in medicine, the envir