Download Free New Antiepileptic Drug Development Book in PDF and EPUB Free Download. You can read online New Antiepileptic Drug Development and write the review.

This volume represents the input of individuals involved in aspects of antiepileptic drug development and discusses how the process can be improved upon and drug evaluation made more effective. Topics range from the theoretical such as ethical issues, to the practical such as study budgets.
Among the key issues addressed are new drug discovery, current trial methodology, innovative trial designs, antiepileptic drug evaluation procedures and criteria, and global drug development. The book highlights methods for the extension of clinical trials to pediatric patients, women of childbearing age, the elderly, and patients with new onset epilepsy. In addition, it provides a timely update on newly released drugs in the United States.
Mechanisms of Action of Antiepileptic Drugs provides a review of all of the mechanisms of action (MOA) of each of the classes of antiepileptic drugs. This is a graphic-intensive text, with detailed illustrations of the various MOA. Introductory and concluding chapters discuss the relevance of MOA to clinical practice. A brief review of neurophysiology of normal and epileptic neurons is followed by individual chapters dedicated to the MOA of each class of antiepileptic drug.
The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.