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Neuroregulatory Mechanisms in Aging.
Thalamic Networks for Relay and Modulation is the third in a series that springs from an idea of Giorgio Macchi who wished to establish periodical updates on thalamic research by bringing to Italy investigators who would engage in an international sharing of ideas and experiences. It reflects the renewed interest in the modulation of thalamic relay activity by intrinsic and extrinsic sources, while continuing to underscore the essential role of the thalamus as the gatekeeper of the cerebral cortex and of the pathways to perception. The papers that form the substance of this book were presented at a Symposium held at the Catholic University, Rome, Italy, in September 1992, as a Satellite to the 15th Annual Meeting of the European Neuroscience Association. The volume is organized into four parts. Part I is basically concerned with developmental and evolutionary approaches. Part II highlights relay functions of visual, motor, and somatosensory relay nuclei and relay functions of the intralaminar nuclei. Part III deals primarily with the pharmacology of thalamic neurons. Part IV emphasizes the mechanisms that underlie the functional assembly of thalamic cells into collectively acting ensembles, largely revealed in rhythmic oscillations, and on the behavioral manifestations that accompany them.
"Will 69 million baby boomers suddenly drop out of the workforce when they turn 65? It is difficult to imagine this generation, with its talent, education, and experience, idling away the last thirty years of life."—From the Foreword, by Robert N. Butler, M.D., The Mount Sinai Medical Center Old age has been historically thought of as a period of frailty and dependence, yet studies show that with the help of advances in health and medicine, current populations will live longer and remain healthier than previous generations. As average life expectancies rise, traditional concepts of retirement need to be reconsidered on all levels—from government policy to business practice to individual life planning. In this volume, leaders in the field of gerontology explore these changing conditions through the concept of "productive aging," which has been developed by leaders in the field to promote older adults' contributions to society in social and economic capacities. Productive Aging: Concepts and Challenges treats the implications of productive aging for the discipline of gerontology and for society in general. The first section defines the principles, historical perspectives, and conceptual frameworks for productive aging. The second section takes a disciplinary approach, treating the biomedical, psychological, sociological, and economic implications of a more capable older generation. The third section considers advances in theories of gerontology, and the fourth section suggests future directions in practice, theory, and research. Contributors: W. Andrew Achenbaum, University of Houston • Scott A. Bass, University of Maryland-Baltimore • Vern L. Bengtson, University of Southern California • James E. Birren, UCLA • Francis G. Caro, University of Massachusetts Boston • Carroll L. Estes, University of California-San Francisco • Marc Freedman, Civic Ventures (co-founder of Experience Corps) • James Hinterlong, Washington University • James S. Jackson, University of Michigan • Jane L. Mahakian, Pacific Senior Services • Harry R. Moody, Robert Wood Johnson Foundation • Nancy Morrow-Howell, Washington University • Philip Rozario, Washington University • James H. Schulz, Brandeis University • Michael Sherraden, Washington University • Alvar Svanborg, University of Illinois-Chicago and Goteburg University, Sweden • Brent A. Taylor, San Diego State University
The second volume in this long-running series presents the usual critical and intensive review chapters divided into five sections but also addresses particular topics of special interest, including drugs and their use, and misuse, among the aged; the nonmedication orientation to treatment of various disorders; the immune system; and clinical procedures in the management of urinary incontinence. As with all the volumes, the contributors represent an international array of leading experts.
A Theory of the Striatum.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Neuroregulation is a challenging and rapidly developing field that holds the key to many currently intractable medical conditions from nervous and mental diseases to stress-related disorders. Advances in Neuroregulation mirrors the broad scope of research in this area with topics ranging from new concepts on the immune system and on the action of a
Social and medical developments have recently led to a dramatic increase in life expectancy. This has inspired the study of organismic changes associated with healthy ageing, in particular the erosion of homeostatic capabilities in multiple endocrine systems. This book reviews advances in the understanding of endocrine facets of ageing. It considers the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal, addressing the influence of external factors on the rates of progression of endocrine sequelae in ageing, the mechanisms that underlie the disarray of endocrine axes in ageing, and the implications of therapeutic reconstitution of hormones in ageing. This book: Considers the mechanisms of ageing and hormonal changes that occur with age. Discusses healthy ageing and the relationships between hormonal changes and pathophysiological conditions such as atherosclerosis and age-related bone loss. Draws together contributions from basic and clinical research, to identify and stimulate promising new research directions.