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Among the many forms of cancer treatment, chemotherapy remains an important part of the arsenal in which Navelbine and Taxotere play a major role.These medicines result from molecules discovered by French researchers of the Institut de Chimie des Substances Naturelles (ICSN) of the CNRS, directed by Pierre Potier. By recounting this history, the authors of this book attempt to illustrate how the work of themselves and others, united in a community, has helped obtain these results. After having explained the strategy of the French policy makers to promote the French chemistry of natural substances, the authors explore how the academic efforts in this field have evolved, and the alignment between science and its applications has become increasingly present. The contributions of the CNRS to the industry, and vice versa, offer an alternative image of public research relationships and industrial research, where CNRS researchers are able to extend the limits of freedom and creativity. It is to account for this complexity that the authors here have chosen to write this history together, which is in a sense exemplary.Due to an association between history and chemistry, this book explains these discoveries by placing them in their specific politic, economic and scientific contexts. - Provides an overview of how the French research system facilitated the discovery of the two molecules, Navelbine and Taxotere, and their anticancer activity - Based on a collaboration between a chemist and an historian of science, technology and innovation - Offers a unique perspective, bringing together the specific knowledge and skills of chemistry and history - Embeds chemistry in the general history thereby opening a window on science in action
Contributions from leading authors in the field of clinical and biological breast cancer research constitute these three chapters: predisposition to breast cancer, carcinogenesis, and early breast cancer screening and management; tumour biology and prognostic; and therapeutics aspects of breast cancer. 21st Meeting of the International Association for Breast Cancer Research, Paris, 1996.
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Taxol, originally derived from the North American Yew tree in 1971, is well-known worldwide as a powerful anticancer agent. Mechanistically, it has a unique microtubule stabilizing activity, and was clinically developed as a therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C., USA. I
Overlooked, even despised by historians of chemistry for many years, the genre of biography has enjoyed a revival since the beginning of this century. The key to its renaissance is the use of the biographical form to provide a contextual analysis of important themes in contrast to the uncritical, almost hagiographic, lives of chemists written in the earlier part of the twentieth century. Bringing together the contributions of scholars active in several different countries, Perspectives on Chemical Biography in the 21st Century leads the reader through emerging questions around sources, and the generic problems faced by authors of biographies, before moving on to discuss aspects more related with physical, theoretical and inorganic chemistry, and facets of 19th century chemistry. In contrast to the letters and diaries of earlier chemists, we are now faced with scientists who communicate by telephone and email, and compose their documents on computers. Are we facing a modern equivalent of the destruction of the Library of Alexandria where all our sources are wiped out electronically?
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Written by two renowned authorities who specialize in the treatment of breast cancer, a surgeon and an oncologist, this lucid step-by-step guide has established itself as the indispensable book women need to make informed decisions about the care that is right for them. Breast cancer will strike one out of every eight women in the United States. Because there have been many important changes in the diagnosis and treatment of breast cancer in the last few years, this fully revised Third Edition contains information on the latest developments in the field, including: • new diagnostic procedures • changes in the treatment of in situ cancer • improved surgical techniques • gene testing • sequencing radiation and chemotherapy • HER-2Neu (Herceptin) • tamoxifen for prevention • bone marrow and stem cell transplants • and more