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Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
First of an eight-volume set, documenting Tukey's work from the 1940s to the 1980s One of the late 20th Century's leading innovators and influences on data analysis, John W. Tukey's discoveries and methods have greatly impacted the work of statisticians throughout the world. The Collected Works of John W. Tukey begins here, with 14 chapters on time series analysis.
These papers illustrate important features characteristic of John Tukey's work, namely the desire to look beyond or beneath conventional set structures, the wish to detect and deal with anomalous behavior, and great technical ingenuity.
This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery.
Combining the strength of the data analysis approach and the power of technology, the new edition features powerful and helpful new media supplements, enhanced teacher support materials, and full integration of the TI-83 and TI-89 graphing calculators.
This book includes a collection of John W. Tukey's papers that demonstrate a number of numerical methods and graphical methods, such as box plots, stem-and-leaf diagrams, and point cloud rotation, for graphics and exploratory data analysis.