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Explores what use can be made of the solution of over 300 protein structures that have now been determined in atomic detail and discusses the effect of this in medicine. Perutz explains how X-ray crystallographic studies have led to new insights into disease and approaches to treatment.
Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers—offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
This monograph provides an account of how the synthetic nitrogen industry became the forerunner of the 20th-century chemical industry in Europe, the United States and Asia. Based on an earlier SpringerBrief by the same author, which focused on the period of World War I, it expands considerably on the international aspects of the development of the synthetic nitrogen industry in the decade and a half following the war, including the new technologies that rivalled the Haber-Bosch ammonia process. Travis describes the tremendous global impact of fixed nitrogen (as calcium cyanamide and ammonia), including the perceived strategic need for nitrogen (mainly for munitions), and, increasingly, its role in increasing crop yields, including in Italy under Mussolini, and in the Soviet Union under Stalin. The author also reviews the situation in Imperial Japan, including the earliest adoption of the Italian Casale ammonia process, from 1923, and the role of fixed nitrogen in the industrialization of colonial Korea from the late 1920s. Chemists, historians of science and technology, and those interested in world fertilizer production and the development of chemical industry during the first four decades of the twentieth century will find this book of considerable value.
"For me and many arbiters, Stewart Reuben's book is our bible." Casto Abundo, Rating Administrator, Elista FIDE Office. This third edition, as well as updated comprehensive and practical information on all aspects of running tournaments, also contains the new FIDE (World Chess Federation) Official Laws of Chess. These Laws were revised at the Chess Olympiad in Calvia, with changes taking effect from July 2005. • Several new chapters have been added on inputting games, websites, junior chess and peripheral events. • The FIDE Title Regulations have been fully revised since the last edition, substantially due to the efforts of Stewart Reuben. What is provided here are the necessary rules, which will enable an organiser or arbiter to run a title norm event. • Various Swiss Pairing Systems are compared critically. • Information given provides what is practically a blue-print to enable an organiser to put together a tournament. Stewart Reuben is internationally recognised as one of the world's foremost chess organisers and arbiters. He is currently Chairman of the FIDE Organizers Committee; Secretary of the Rules and Tournament Regulations Committee, member of the Title and Ratings Committee and of the Qualification Commission. He is also past Chairman of the British Chess Federation. He has officiated at and/or organised numerous top-level events, including the World Championship. He holds three FIDE titles: Arbiter, Organizer and Candidate Master.