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The Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic reference on clinical research ethics. Under the editorship of experts from the U.S. National Institutes of Health of the United States, the book's 73 chapters offer a wide-ranging and systematic examination of all aspects of research with human beings. Considering the historical triumphs of research as well as its tragedies, the textbook provides a framework for analyzing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the contributors examine issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent to focused consideration of international research ethics, conflicts of interests, and other aspects of responsible conduct of research. The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advances scholarship in the field of human subjects research. Comprehensive in scope and depth, this book will be a crucial resource for researchers in the medical sciences, as well as teachers and students.
This practical handbook includes all the main clinical trial and general research terms, and is illustrated with real-life examples, diagrams and tables. It also includes material on research ethical committees, and incorporates recent international developments such as the EU Clinical Trials Directive. The research methods and issues identified are universal, crossing countries and disciplines. It can be used as a reference tool, an introduction to learning about clinical trials, as a refresher to those involved in clinical research, or to check that the correct terms are being used in the correct context. Readily available references are included that can be used by the reader to further support their own work.
Continuous update in critical care medicine is a real challenge due to the growing dimensions of its contents; these elements are the result of new research acquisitions, and of those clinical situations where the physician is able to intervene at a given moment, with the use of effective prevention techniques. They are also the result of new technologies able to define complex sub-clinical diagnostic aspects; lastly, they are the result of effective therapeutic techniques available, and of treatment strategies able to influence radically and positively the patient's clinical course. Critical care medicine is playing a key role in the most advanced environments, as it represents a cross-sectional field of action, involving several specialties, such as anesthesiology, general medicine, surgery, pediatrics.
This classic textbook has provided students of medical law and ethics with a framework for exploring this fascinating subject for over 30 years. Providing coverage of all of the topics found on medical law courses, it gives an overview of the inter-relationship between ethical medical practice and the law. Medical law is significantly shaped by the courts, and as such this book provides extensive coverage of recent judicial decisions as well as statutory developments. The new edition continues to evolve to reflect changes in the law and shifting ethical opinions.
This book examines the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective.
Some developing biotechnologies challenge accepted legal and ethical norms because of the risks they pose. Xenotransplantation (cross-species transplantation) may prolong life but may also harm the xeno-recipient and the public due to its potential to transmit infectious diseases. These trans-boundary diseases emphasise the global nature of advances in health care and highlight the difficulties of identifying, monitoring and regulating such risks and thereby protecting individual and public health. Xenotransplantation raises questions about how uncertainty and risk are understood and accepted, and exposes tensions between private benefit and public health. Where public health is at risk, a precautionary approach informed by the harm principle supports prioritising the latter, but the issues raised by genetically engineered solid organ xenotransplants have not, as yet, been sufficiently discussed. This must occur prior to their clinical introduction because of the necessary changes to accepted norms which are needed to appropriately safeguard individual and public health.