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This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
"For over 130 years, Imperial Oil dominated Canada's oil industry. From Petrolia to Turner Valley, Imperial was always nearby and ready to take charge. Their 1947 discovery of crude oil in Leduc, Alberta transformed the industry and the country. But from 1899 onwards, two-thirds of the company was owned by an American giant, making Imperial Oil one of the largest foreign-controlled multinationals in Canada. "Imperial Standard" is the first full-scale history of Imperial Oil. It illuminates Imperial's longstanding connections to Standard Oil of New Jersey, also known as Exxon Mobil. Although this relationship was often beneficial to Imperial, allowing them access to technology and capital, it also came at a cost. During the energy crises of the 1970s and 80s, Imperial was assailed as the embodiment of foreign control of Canada's natural resources, and in the 1990s it followed Exxon's lead in resisting charges that the oil industry contributes to climate change. Graham D. Taylor draws on an extensive collection of primary sources, including both the Imperial Oil and Exxon Mobil archives, to explore the complex relationship between the two companies. This groundbreaking history provides unprecedented insight into one of Canada's most influential oil companies as well as the industry itself."--
ETHNIC DERMATOLOGY Principles and Practice Richly pigmented skin is the most common skin type internationally Historically, dermatology has focused on white skin. But rich pigmentation can lead to differences in presentation, disease course and outcome, and reaction to treatment. Some dermatologic conditions are seen either predominantly or exclusively in richly pigmented skin. Ethnic Dermatology: Principles and Practice provides a practical approach to the dermatology of nonwhite skin. Written from a global perspective to include Asian, African-Caribbean and North African skin types, it covers all the bases of dermatology including: Grading scales in dermatologic disease Pediatric dermatology Dermatology and systemic disease Drug eruptions Hair and scalp disorders Cosmetic dermatology. With a central focus on practical action from an international cast of authors, Ethnic Dermatology: Principles and Practice gives you the clinical tools you need when skin color matters.
This second editionis a ground-breaking clinical text with a strong emphasis on rigorous evidence. Leaders in the field discuss best practice in the light of systematic reviews and randomised control trials, and how best to treat where the information is less clear. Case histories provide intriguing discussions on how to apply the evidence in real life situations. Evidence-based Cardiology also includes free access to the latest evidence, which is automatically posted on a companion website.