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The MPS Language Workbench, Volume I (third edition). The first volume of the series is both a simple introduction to the JetBrains MPS language workbench and a complete reference manual. The Meta-Programming System (MPS) is a new kind of tool called a language workbench that simply stated makes it easier and more fun to write programs. With traditional programming, it is common to choose one programming language to solve a problem and being limited by this choice. When working with MPS you can use and combine different languages to solve a problem. You can also create simple languages (e.g., Domain Specific Languages) or extend existing ones when the languages available do not exactly meet the evolving needs of the problem at hand. The languages that you create with MPS will integrate nicely with languages developed by others. MPS is open-source and can be obtained from http://jetbrains.com/mps or http://github.com/JetBrains/MPS. This book explains the MPS programming paradigm and gradually introduces the reader to the many features of the MPS platform. This book may yet be the simplest way to discover the MPS language workbench and the powerful new approach to programming that this tool offers. The third edition of this book describes MPS 3.3.
The House of Commons is one of Britain's mysterious institutions: constantly in the news yet always opaque. In this ground-breaking anthropological study of the world's most famous parliament, Emma Crewe reveals the hidden mechanisms of parliamentary democracy. Examining the work of Members of Parliament – including neglected areas such as constituencies and committees – this book provides unique insights into the actual lives and working relationships of parliamentarians. 'Why do the public loathe politicians but often love their own MP?' the author asks. The antagonistic façade of politics irritates the public who tend to be unaware that, backstage, democracy relies on MPs consulting, compromising and cooperating across political parties far more than is publicly admitted. As the book shows, this is only one of myriad contradictions in the labyrinths of power. Based on unprecedented access and two years of interviews and research in the Palace of Westminster and MPs' constituencies, The House of Commons: An Anthropology of MPs at Work challenges the existing scholarship on political institutions and party politics. Moving beyond the narrow confines of rational choice theory and new institutionalism, Emma Crewe presents a radical alternative to the study of British politics by demonstrating that all of its processes hinge on culture, ritual and social relations. A must-read for anyone interested in political anthropology, politics, or the Westminster model.
This volume contains an Open Access chapter. The present volume of Comparative Social Research offers a broad set of comparative studies of elites, stretching from the Arab Spring in Tunisia and Egypt to women's political leadership in Brazil and Germany, via attainment of elite positions among minorities in France and the US.
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Published since 1928, the Political Handbook of the World provides timely, thorough, and accurate political information with more in-depth coverage of current political controversies and political parties than any other reference guide. The updated 2016–2017 Edition continues this legacy as the most authoritative source for finding complete facts and analysis on each country’s governmental and political makeup. Political science and international relations scholars have revised this edition, and made understanding complex foreign affairs andpolitical situations easy and accessible. With more than 200 entries on countries and territories throughout the world, housed in one place, these volumes are renowned for their extensive coverage of all major and minor political parties and groups in each political system. They also provide names of key ambassadors and international memberships of each country, plus detailed profiles of more than 30 intergovernmental organizations and United Nations agencies. This comprehensive update will include coverage of current events, issues, crises, and controversies from the course of the last two years, including: The closely-watched U.S. presidential election The effect of the Brexit referendum and installment of a new British prime minister The extensive investigation and subsequent impeachment of Brazil’s president The far-reaching impact of the “Panama Papers” scandal Changes in U.S.–Cuba diplomatic relations and the reopening of their embassies The unconstitutional declaration of Gambia as an Islamic State Sentiments about the migrant and refugee crisis across Europe and the influence on policy Also, the new “For Further Reference” feature included for every country entry directs readers to additional resources to continue their research.
Gender inequality remains an issue of high relevance, and controversy, in society. Previous research shows that language contributes to gender inequality in various ways: Gender-related information is transmitted through formal and semantic features of language, such as the grammatical category of gender, through gender-related connotations of role names (e.g., manager, secretary), and through customs of denoting social groups with derogatory vs. neutral names. Both as a formal system and as a means of communication, language passively reflects culture-specific social conditions. In active use it can also be used to express and, potentially, perpetuate those conditions. The questions addressed in the contributions to this Frontiers Special Topic include: • how languages shape the cognitive representations of gender • how features of languages correspond with gender equality in different societies • how language contributes to social behaviour towards the sexes • how gender equality can be promoted through strategies for gender-fair language use These questions are explored both developmentally (across the life span from childhood to old age) and in adults. The contributions present work conducted across a wide range of languages, including some studies that make cross-linguistic comparisons. Among the contributors are both cognitive and social psychologists and linguists, all with an excellent research standing. The studies employ a wide range of empirical methods: from surveys to electro-physiology. The papers in the Special Topic present a wide range of complimentary studies, which will make a substantial contribution to understanding in this important area.
This book presents the first detailed inquiry into the nature of cross-border drug trafficking between Laos People’s Democratic Republic and Vietnam, using an exploratory approach. It draws upon qualitative and quantitative methods, case studies, interviews and survey data from criminal investigation police and drug-related crimes officers (CIPDRC) from six border provinces which are directly and indirectly involved in investigating these cross-border cases. The author demonstrates that drug markets in Vietnam are not controlled by monopolistic, hierarchical organizations or ‘cartels’ but small structures, based on family ties and fellow-countrymen relations, which are fluid and loosely organized. They are very adaptable and sophisticated with diverse modus operandi and multiple divisions of labour which present particular challenges to law enforcement agencies, which the author discusses.
This volume offers the most significant analysis of how parliament re-emerged in Myanmar in the span of a post-junta decade (2011-2021).
'Complete Public Law' combines extracts from key primary and secondary materials with jargon-free text to provide a resource for the student new to the study of constitutional and administrative law.