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Organocopper compounds are now an integral part of every modern synthesis laboratory, allowing important stages of synthesis to be carried out in an elegant fashion. Yet a certain amount of experience is needed if they are to be used effectively. Non-experts in the field often have difficulty in choosing the most suitable reagent for a particular substrate and the prerequisites for the reaction.This manual, edited by Norbert Krause, answers such questions, since it contains all the useful tips and tricks on organocopper compounds - information gained from personal experience by the international team of authors. This allows those working in laboratories in both academia and industry to determine the optimal reagent for their needs using the substrates available for reaction and the desired products. The result is a more effective use of these synthesis tools in everyday laboratory practice.
Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.
A laboratory manual detailing the procedures for the preparation and application of a group of highly specific reagents, and how to overcome the many problems associated with their use. Also includes a historical overview of organocopper chemistry; a description of starting material purification; and guidelines to the reaction, which are usually characterized by a high chemo-, regio-, and stereoselectivity. Begins a series providing practical and accessible laboratory guides for new and experienced researchers unfamiliar with the particular area. Annotation copyright by Book News, Inc., Portland, OR
This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
This book reflects the increasing interest among the chemical synthetic community in the area of asymmetric copper-catalyzed reactions, and introduces readers to the latest, most significant developments in the field. The contents are organized according to reaction type and cover mechanistic and spectroscopic aspects as well as applications in the synthesis of natural products. A whole chapter is devoted to understanding how primary organometallics interact with copper to provide selective catalysts for allylic substitution and conjugate addition, both of which are treated in separate chapters. Another is devoted to the variety of substrates and experimental protocols, while an entire chapter covers the use on non-carbon nucleophiles. Other chapters deal with less-known reactions, such as carbometallation or the additions to imines and related systems, while the more established reactions cyclopropanation and aziridination as well as the use of copper (II) Lewis acids are warranted their own special chapters. Two further chapters concern the processes involved, as determined by mechanistic studies. Finally, a whole chapter is devoted to the synthetic applications. This is essential reading for researchers at academic institutions and professionals at pharmaceutical or agrochemical companies.
A comprehensive and up-to-date overview of alkyne chemistry, taking into account the progress made over the last two decades. The experienced editors are renowned world leaders in the field, while the list of contributors reads like a "Who's Who" of synthetic organic chemistry. The result is a valuable reference not only for organic chemists at universities and in the chemical industry, but also for biologists and material scientists involved in the modern synthesis of organic compounds and materials.
Authored by one of the world?s leading synthetic chemists in the field, this reference presents modern enolate chemistry with an emphasis on metal O-enolates in asymmetric synthesis. While great care is taken to cover novel, successful concepts, such classical methods as the famous Evans enolates are equally highlighted. Throughout the book representative reaction procedures are presented, thus helping readers to find the best solution for their own synthetic problem. Of high interest to synthetic chemists in academia, as well as the pharmaceuticals, agrochemicals and fine chemicals industries.
The present volume finalizes the coverage of organocopper compounds. A complete formula and ligand index for the Gmelin organocopper series will appear shortly as" Organa copper Compounds" 5. The volume describes mononuclear compounds with ligands bonded by two or more carbon atoms as well as all di- to octanuclear and polymeric compounds. Mononuclear compounds with ligands bonded by one carbon atom have already been described in Vol umes 1 (published in 1985), 2 (published in 1983), and 3 (published in 1986). As structural elucidation in organocopper chemistry gained more attention only in the last few years, the terms "mononuclear", "dinuclear" etc. have been used as explained in "Organocopper Compounds" 1, 1985, pp. 3/4: all compounds are treated with their small est formula unit unless a higher nuclearity has been proved. As a consequence, most of the species treated in volumes 1 to 3 are described there because of insufficient structural information although they are alleged not to be monomeric. This way, many of the better characterized compounds appear in the present volume which is reflected by the more than eighty X-ray structure figures. Generally, nuclearity and structure are not only deter mined by the coordination properties of the ligands, but also by steric requirements, and may therefore widely differ for analogous compounds. For abbreviations and dimensions used throughout this volume, see p. X. Frankfurt am Main, July 1987 Johannes Fussel Remarks on Abbreviations and Dimensions Most compounds and reagents in this volume are presented in tables.
With its comprehensive overview of modern reduction methods, this book features high quality contributions allowing readers to find reliable solutions quickly and easily. The monograph treats the reduction of carbonyles, alkenes, imines and alkynes, as well as reductive aminations and cross and heck couplings, before finishing off with sections on kinetic resolutions and hydrogenolysis. An indispensable lab companion for every chemist.