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An overview of the importance and consequences of asymmetry from molecules to the macroscopic world As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features: An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.
Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.
A TIME and NEW YORK TIMES TOP 10 BOOK of the YEAR * New York Times Notable Book and Times Critic’s Top Book of 2018 NAMED ONE OF THE BEST BOOKS OF 2018 BY * Elle * Bustle * Kirkus Reviews * Lit Hub* NPR * O, The Oprah Magazine * Shelf Awareness The bestselling and critically acclaimed debut novel by Lisa Halliday, hailed as “extraordinary” by The New York Times, “a brilliant and complex examination of power dynamics in love and war” by The Wall Street Journal, and “a literary phenomenon” by The New Yorker. Told in three distinct and uniquely compelling sections, Asymmetry explores the imbalances that spark and sustain many of our most dramatic human relations: inequities in age, power, talent, wealth, fame, geography, and justice. The first section, “Folly,” tells the story of Alice, a young American editor, and her relationship with the famous and much older writer Ezra Blazer. A tender and exquisite account of an unexpected romance that takes place in New York during the early years of the Iraq War, “Folly” also suggests an aspiring novelist’s coming-of-age. By contrast, “Madness” is narrated by Amar, an Iraqi-American man who, on his way to visit his brother in Kurdistan, is detained by immigration officers and spends the last weekend of 2008 in a holding room in Heathrow. These two seemingly disparate stories gain resonance as their perspectives interact and overlap, with yet new implications for their relationship revealed in an unexpected coda. A stunning debut from a rising literary star, Asymmetry is “a transgressive roman a clef, a novel of ideas, and a politically engaged work of metafiction” (The New York Times Book Review), and a “masterpiece” in the original sense of the word” (The Atlantic). Lisa Halliday’s novel will captivate any reader with while also posing arresting questions about the very nature of fiction itself.
An overview of the importance and consequences of asymmetry from molecules to the macroscopic world As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features: An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.
Breast Imaging presents a comprehensive review of the subject matter commonly encountered by practicing radiologists and radiology residents in training. This volume includes succinct overviews of breast cancer epidemiology, screening, staging, and treatment; overviews of all imaging modalities including mammography, tomosynthesis, ultrasound, and MRI; step-by-step approaches for image-guided breast interventions; and high-yield chapters organized by specific imaging finding seen on mammography, tomosynthesis, ultrasound, and MRI. Part of the Rotations in Radiology series, this book offers a guided approach to breast imaging interpretation and techniques, highlighting the nuances necessary to arrive at the best diagnosis and management. Each chapter contains a targeted discussion of an imaging finding which reviews the anatomy and physiology, distinguishing features, imaging techniques, differential diagnosis, clinical issues, key points, and further reading. Breast Imaging is a must-read for residents and practicing radiologists seeking a foundation for the essential knowledge base in breast imaging.
Science, Paradox, and the Moebius Principle confronts basic anomalies in the foundations of contemporary knowledge. Steven M. Rosen deals with paradoxes that call into question our conventional way of thinking about space, time, and the nature of human experience. Rosen's contribution is unique in at least five respects: 1) He provides an unparalleled integration of modern theoretical science and contemporary phenomenological thought. 2) He features a section of dialogue with David Bohm, who contributed greatly in fields of major concern to the book. 3) He sets forth a process theory and philosophy, presenting a concept in which space, time, and consciousness undergo a continuous internal transformation and organic growth. 4) He furnishes a highly specific account of dialectical change, employing geometric forms that bring the dynamics of paradox into focus with unprecedented clarity. 5) He is transdisciplinary and provides transcultural bridges between the "two cultures" of science and the humanities.
Plants exhibit forms of asymmetry analogous to "handedness" in bilaterally symmetrical animals. This book explores the evolutionary significance and development of asymmetry. Examples of genetic control include the direction of tendril or stem coiling of many climbing plants; the so-called spiral phyllotaxy and floral taxy; and contorted petal arrangement is another kind of left- right symmetry in plants; the direction of contortion is fixed in some but not in other plants. The book will underscore tha all phenomena related to handedness start during embryogenesis itself, with the occurrence of embryo rotation. Key selling features: First consolidated book on Plant Handedness Relates handedness, asymmetry and chirality to the evolution of different organizational levels in plant biology Emphasizes handedness as a vital governing force in plant functional evolution Provides a new perspective, hitherto ignored, into plant developemtn and evolution Describes how an age-old phenomenon can give scope for investigation from a very modern interdisciplinary approach
· This textbook has been designed to meet the needs of B.Sc. Third Semester students of Physics as per Common Minimum Syllabus prescribed for all Uttar Pradesh State Universities and Colleges under the recommended National Education Policy 2020. · Maintaining the traditional approach to the subject, this textbook comprehensively covers both the parts of the theory papers, namely, Electromagnetic Theory and Modern Optics as well as the Practical Paper. · The theory part includes important theoretical topics such as Electrostatics, Magnetostatics, Time Varying Electromagnetic Fields, Electromagnetic Waves, Interference, Diffraction, Polarisation and Lasers are aptly discussed to give a complete overview of Electromagnetic Theory & Modern Optics. · The practical part covers experiments which are on Carey Foster bridge, Earth inductor, deflection and vibration magnetometer, study of variation of magnetic field along the axis of a single and double coil. Ballistic galvanometer-based experiments to determine high resistance, low resistance, self-inductance and comparison of capacitances are explained in detail.