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The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.
Collective Behavior of Magnetic Micro/Nanorobots: Control, Imaging, and Applications reviews recent advances in the design and construction of magnetic collective micro/nanorobot systems, and promotes the bridging of the gap between their theoretical investigation and practical applications. By summarizing the recent progress in control, imaging, and biomedical applications of collective micro/nanorobots, the authors show the big picture of micro/nanorobotics and the roadmap of collective micro/nanorobots. They then discuss the control, imaging, and biomedical applications of collective micro/nanorobots, respectively, demonstrating the state-of-the-art techniques and ideas for designing systems of collective micro/nanorobots that can help researchers have a better understanding and further stimulate the development of such an exciting field. This book is suitable for scientists, engineers, and students involved in the study of robotics, control, materials, and mechanical/electrical engineering.
Acoustic Technologies in Biology and Medicine Complete, balanced resource encompassing all required technical, theoretical, and applied multidisciplinary knowledge related to acoustics Taking a multidisciplinary approach involving fluid mechanics, physics, chemistry, electronics, and the life sciences to provide a unified and competent overview of the field, Acoustic Technologies in Biology and Medicine covers the fundamental principles of acoustic wave generation and propagation, different acoustic systems and technologies with the interplay of physical forces, theoretical foundations, and the state-of-the-art biomedical applications of acoustics. State-of-the-art applications of acoustics in biology and medicine are presented, including single cell and organism manipulation, acoustic biosensing, cancer cell isolation (liquid biopsy), cell/tissue stimulation and ablation, micro-robot actuation, acoustic imaging, and drug delivery. Contributed to and edited by highly qualified professionals with significant experience in the field, Acoustic Technologies in Biology and Medicine covers sample topics such as: Materials for acoustic wave generation and modulation, ultrasound imaging, and photoacoustic imaging and sensing for biomedical applications Therapeutic ultrasound, application of ultrasound responsive reagents for drug delivery systems, and acoustic levitation and acoustic holograms Application of ultrasonic waves in bioparticle manipulation and separation, acoustic biosensors, and acoustic micro and nanorobots in medicine Different technologies of acoustic systems, including bulk and surface acoustic wave-based platforms, acoustic imaging, acoustic sensors, and acoustic levitators A cornerstone reference bridging the gap between rapidly advancing acoustic technologies with state-of-the-art applications in biology and medicine, Acoustic Technologies in Biology and Medicine is an essential resource on the subject for biophysicists, materials scientists, biotechnologists, bioengineers, sensor developers, electronics engineers, and all professionals in the greater biotechnological industry.
Demands for high-performance micro/nano manipulations, from the manufacture of microelectronic and photonic devices, biomedical apparatus, nanoscience and nanotechnology, renewable energy, environment protection, and high-end appliances, have been rapidly increasing in recent years. However, there are very few books on ultrasonic manipulation technology, which is one of the important means in micro/nano manipulations.This unique title gives the basic physical principles of ultrasonic micro/nano manipulations, and highlights methods of implementing these principles. The nonlinear effects of ultrasound are described in details after piezoelectric transduction and acoustic field are introduced and discussed. Numerous important examples are given in this book, to help readers better understand the applications of these principles and characteristics of ultrasonic manipulators utilizing these principles. The examples cover the manipulations of micro solids, nanoscale entities, droplets and microfluid.This indispensable book will contribute positively to the development and application of micro/nano manipulation technology.
This book presents the select proceedings of the 48th National Conference on Fluid Mechanics and Fluid Power (FMFP 2021) held at BITS Pilani in December 2021. It covers the topics such as fluid mechanics, measurement techniques in fluid flows, computational fluid dynamics, instability, transition and turbulence, fluid‐structure interaction, multiphase flows, micro- and nanoscale transport, bio-fluid mechanics, aerodynamics, turbomachinery, propulsion and power. The book will be useful for researchers and professionals interested in the broad field of mechanics.
Modeling of Microscale Transport in Biological Processes provides a compendium of recent advances in theoretical and computational modeling of biotransport phenomena at the microscale. The simulation strategies presented range from molecular to continuum models and consider both numerical and exact solution method approaches to coupled systems of equations. The biological processes covered in this book include digestion, molecular transport, microbial swimming, cilia mediated flow, microscale heat transfer, micro-vascular flow, vesicle dynamics, transport through bio-films and bio-membranes, and microscale growth dynamics. The book is written for an advanced academic research audience in the fields of engineering (encompassing biomedical, chemical, biological, mechanical, and electrical), biology and mathematics. Although written for, and by, expert researchers, each chapter provides a strong introductory section to ensure accessibility to readers at all levels. - Features recent developments in theoretical and computational modeling for clinical researchers and engineers - Furthers researcher understanding of fluid flow in biological media and focuses on biofluidics at the microscale - Includes chapters expertly authored by internationally recognized authorities in the fundamental and applied fields that are associated with microscale transport in living media
This book describes the substantial progress recently made in the development of micro and nanorobotic systems, utilizing magnetic, optical, acoustic, electrical, and other actuation fields. It covers several areas of micro and nanorobotics including robotics, materials science, and biomedical engineering. Field-Driven Micro and Nanorobots for Biology and Medicine provides readers with fundamental physics at the micro and nano scales, state-of-the-art technical advances in field-driven micro and nanorobots, and applications in biological and biomedical disciplines.
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. - Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles - Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems - Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology
This book is focused on the attractive emerging field of micro-/nanorobot swarms (microswarms). It introduces fundamental understandings of various microswarms, including pattern generation, transformation, locomotion, and imaging. This book also demonstrates applications of micro-/nanorobot swarms in different fields, such as biomedical, environmental, and electrical applications. The detailed theoretical analysis and experimental demonstrations in this book provide readers ranging from students to researchers with a realistic picture of progress achieved in the field of micro-/nanorobot swarms. ​
Ultrasonic nano/microfabrication, handling and driving is an emerging actuation technology, which utilizes ultrasonic vibration and the physical effects of ultrasonic vibration in fluids and solids to implement the fabrication, handling and driving of nano/micro scale objects. This book provides readers with the fundamentals, principles and characteristics of the ultrasonic devices for nano/micro fabrication, handling and driving, and design methods of the devices. • Introduces fundamental concepts and offers examples of ultrasonic nano fabrication, including ultrasonic nano rolling, cutting and coating methods. • Features a wealth of examples to illustrate the ultrasonic concentration and ultrasonic tweezers. • Explains the principles of ultrasonic driving of gas molecules and demonstrates their applications in high-performance gas sensor systems and metal-air flow batteries. • Teaches the principles of ultrasonic driving of microfluids and their applications in metal-air flow batteries and cooling of small solid heat sources. • Provides examples for the finite element method (FEM) modeling and computation of ultrasonic devices for nano/micro fabrication, handling and driving. • Summarizes the current and future trends in ultrasonic nano/microfabrication, handling, and driving. This book shares the advances, methods and applications of ultrasonic micro/nano fabrication techniques for entry-level and advanced readers working on nano/microfabrication, gas sensing, biological sensing, metal-air batteries, electronic component cooling, and other related areas.