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This interdisciplinary book gives a comprehensive survey of the state-of-the-art: from applications and trends in fluorescence techniques in science to medicine and engineering. Written for practitioners and researchers in industry and academia, it covers fields like environmental and materials science, biology, medicine, physics and chemistry. Moreover, it reports on such new and breathtaking methods as ultra-fast time-resolved or single molecule spectroscopy, gives examples of applications in the fields of electroluminescent polymers, visualization of membrane potentials in neurons and fluorescence imaging of the brain.
This first volume in the new Springer Series on Fluorescence brings together fundamental and applied research from this highly interdisciplinary and field, ranging from chemistry and physics to biology and medicine. Special attention is given to supramolecular systems, sensor applications, confocal microscopy and protein-protein interactions. This carefully edited collection of articles is an invaluable tool for practitioners and novices.
Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
An accessible, introductory text explaining how to select, set up and use optical spectroscopy and optical microscopy techniques.
The increased use of fluorescence techniques is greatly enhanced by the improved instrumentation pioneered by inventive scientists and now made available commercially by several high-tech companies. Moreover, the design and development of many new molecular probes with higher selectivity for specific microenvironmental properties has stimulated many new researchers to employ fluorescence techniques for solving their problems. This topic book, the second in his series, reflects this exciting scientific progress and deals, among others, with new approaches and new probes in fluorescence spectroscopy, single molecule fluorescence, applications in biomembrane and enzyme studies and imaging of living cells.
Along with the traditional optical window, many new windows have been opened on galaxies in the last two decades, made possible by new developments in groundbased detectors and by space missions that allow detection of photons that are otherwise absorbed by the Earth's atmosphere. Galaxies can now be observed in the radio, submillimeter, IR, optical, UV, X- and gamma-ray bands, each window allowing us to learn more about galactic components and properties. These developments have also imposed the view that a deeper understanding of even normal galaxies requires a panchromatic approach, making use of all of the data gathered from the different windows to synthesize a comprehensive physical image of these complex astronomical systems. Windows on Galaxies presents a comprehensive view of galaxies through all the available windows, bringing together both theoretical and experimental approaches in the form of a series of reviews reporting the most recent developments complemented by contributed talks and discussions. TEXT NO. 2 The sixth workshop of the Advanced School of Astronomy examined galaxies through all available wavelength windows. Over the last twenty years, new wavelength windows have been opened in astronomy which have created many new possibilities for the observation of the properties of galaxies. The outcome of the meeting clearly stated that the approach towards the studying of galaxies should be panchromatic. Each window, from radio to gamma-rays, shows different components, and a synthesis of this knowledge presents astronomers with a comprehensive physical image of these astronomical systems: star formation, evolution of galaxies, molecular contents, gas flows, interstellar matter and properties of galaxies in the several wavelength fields are discussed in this volume.
Fingerprints constitute one of the most important categories of physical evidence, and it is among the few that can be truly individualized. During the last two decades, many new and exciting developments have taken place in the field of fingerprint science, particularly in the realm of methods for developing latent prints and in the growth of imag
The detection of single molecules opens up new horizons in analytical chemistry, biology and medicine. This discipline, which belongs to the expanding field of nanoscience, has been rapidly emerging over the last ten years. This handbook provides a thorough overview of the field. It begins with basics of single molecule detection in solution, describes methods and devices (fluorescense correlation spectroscopy, surface enhanced Raman scattering, sensors, especially dyes, screening techniques, especially confocal laser scanning microscopy). In the second part, various applications in life sciences and medicine provide the latest research results. This modern handbook is a highly accessible reference for a broad community from advanced researchers, specialists and company professionals in physics, spectroscopy, biotechnology, analytical chemistry, and medicine. Written by leading authorities in the field, it is timely and fills a gap - up to now there exists no handbook concerning this theme.