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Insulin dysregulation mediates the increased risk for laminitis associated with the two most common equine endocrinopathies, pituitary pars intermedia dysfunction (PPID) and the equine metabolic syndrome (EMS). This thesis aimed to describe the metabolic profile of horses with this condition to help elucidate the cause for the increased insulin production it elicits and possibly uncover some pathomechanisms leading to laminitis. Besides identifying metabolites correlated to the level of the insulin response to an oral glucose test, such as carnitine, arginine and DOPA, this project revealed the potential of such molecules in recognizing horses with insulin dysregulation without complex diagnostic tests. Additionally, it allowed to concretely quantify the reduction of the insulin response to oral carbohydrates following weight loss, while differentiating the respective metabolic impact of weight gain and worsened insulin dysregulation. Lastly, metabolites associated with subsequent laminitis were described. Altogether, the results provided new concepts for the identification of insulin dysregulation, supported an association between this condition and vascular dysfunction, helped distinguish the metabolic impact of weight variations from the effect of insulin dysregulation, and suggested that carnitine and arginine could be investigated as nutritional supplements to treat insulin dysregulation.
The first book dedicated to this common, serious, and complex equine disease, Equine Laminitis is the gold-standard reference to the latest information on every aspect of the disease and its treatment. Provides the first book devoted specifically to equine laminitis Discusses the current state of knowledge on all aspects of the disease, including its history, relevant anatomical considerations, pathophysiology, the diagnostic workup, and clinical treatment Presents 50 chapters written by leading international experts, under the editorship of the foremost authority on equine laminitis Offers a thorough understanding of this common affliction, grounded in the scientific literature Describes effective prevention and treatment plans
Nutritional Management of Equine Diseases and Special Cases offers a concise, easy-to-comprehend text for equine veterinarians with questions about commonly encountered nutritional problems. Assists veterinarians in supporting equine patients with special nutritional needs Focuses on nutritional problems and impact on different body systems Covers ponies, miniature horses, draft horses, donkeys, and mules Offers complete coverage of common diseases and problems helped by nutrition Includes useful chapters on poisonous plants and mycotoxins
Stay up-to-date on the latest advances and current issues in equine medicine with this handy reference for the busy equine practitioner, large animal veterinarian, or student. This edition of Current Therapy in Equine Medicine brings you thorough coverage and expert advice on selected topics in areas that have seen significant advances in the last 5 years. Content emphasizes the practical aspects of diagnosis and treatment and provides details for therapeutic regimens. Arranged primarily by body system, the text also features sections on infectious diseases, foal diseases, nutrition, and toxicology. With this cutting-edge information all in one reliable source, you'll increase your awareness of key therapies in less time. Focuses on the latest therapy for equine diseases, emphasizing detailed discussions and the most reliable and current information. Organized approach to important problems brings you up-to-date, practical information organized by organ system. Concise, easy-to-read format saves you time; most articles provide essential information in 2 to 5 pages. Renowned group of contributors share their expertise on the timely topics you need to know about. Photos enhance information. Line drawings illustrate important concepts. NEW! Emerging topics include issues such as disinfection in equine hospitals; complimentary modalities to traditional medicine; chemotherapy for oncological diseases; and protecting yourself with medical records. Each section has NEW topics including medical management of critically ill foals in the field; oral cavity masses; radiology of sinuses and teeth; biochemical tests for myocardial injury; protozoal myeloencephalitis update; management of bladder uroliths; skin grafting; managing the high-risk pregnancy; shock wave therapy; and more!
This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Carrie Finno, focuses on Equine Genetic Diseases. Topics include: Genetics, Genomics, and Emergent Precision Medicine 12 years post Equine Reference Genome; Equine SNP Genotyping Arrays; Next-generation Sequencing; Genetic Testing in the Horse; Genetics of Cardiovascular Disease; Genetics of Respiratory Disease; Genetics of Neurological Disease; Genetics of Immune Disease; Genetics of Orthopedic Disease; Genetics of Ocular Disease; Genetics of Skin Disease; Genetics of Endocrine and Metabolic Disease; Genetics of Muscle Disease; Genetics of Laminitis; Genetics of Reproductive Diseases; and Genetics of Behavioral Traits.
Glucose and lipid metabolism in metabolically and endocrinologically diseased horses
Nutritional Management of Equine Diseases and Special Cases offers a concise, easy-to-comprehend text for equine veterinarians with questions about commonly encountered nutritional problems. Assists veterinarians in supporting equine patients with special nutritional needs Focuses on nutritional problems and impact on different body systems Covers ponies, miniature horses, draft horses, donkeys, and mules Offers complete coverage of common diseases and problems helped by nutrition Includes useful chapters on poisonous plants and mycotoxins
Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures
This book contains the latest scientific findings on nutrition and training of racing and sport horses discussed by renowned experts during the Equine NUtrition and TRAining COnference 2009. Furthermore, state of the art reviews are published on the prevention and treatment of gastric ulcers, on the effects of diet and feeding regimens on performance, on the principles and practice of plyometric training for the development of strength and on how not to train sport horses. Finally, expanded abstracts of peer reviewed original research presented during the conference are included. All those concerned with training, riding and feeding in the equine industry will benefit from this valuable resource.
Equine Applied and Clinical Nutrition is a comprehensive text resource on the nutrition and feeding management of horses. Over 20 experts from around the world share their wisdom on a topic of central relevance to all equine practitioners and the equine community generally. Both basic and applied (including healthy and diseased animals) nutrition and feeding management of horses and other equids (i.e. ponies, donkeys, wild equids) are covered. The book will appeal to a wide audienc: undergraduate and post-graduate students in equine science and veterinary medicine, veterinarians, equine nutritionists, horse trainers and owners. The clinical component will strengthen the appeal for equine veterinarians. Equine Applied and Clinical Nutrition will be a "must have" for anyone involved in the care of horses, ponies and other equids. The book is divided into 3 parts: - Basic or core nutrition in this context refers to digestive physiology of the horse and the principles of nutrition. - Applied nutrition deals with the particular types of foods, and how to maintain an optimum diet through various life stages of the horse. You might characterize this aspect as prevention of disease through diet. - Clinical nutrition covers various diseases induced by poor diet, and their dietary treatment and management. It also looks at specific feeding regimes useful in cases disease not specifically induced by diet. - Authoritative, international contributions - Strong coverage of clinical aspects either omitted from or only sparsely dealt with elsewhere - Full colour throughout - The only clinical equine nutrition book