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This book is intended for undergraduates studying the biological and medical sciences. The field of excitable cell physiology is one which is found quite baffling by a significant minority of these students. My aim here is to provide a brief introductory account, based on a conceptual approach, rather than on a mathematical or historical description. Once the student has grasped certain basic ideas concerning excitable cell function, the individual examples which follow fit into a well-defined pattern. No attempt has been made to give credit in appropriate measure to the many scientists who have contributed to this field. The further reading cited has been chosen with the reader alone in mind. I would like to thank Tim Cripps for help and advice, also Charlie Tomson and Michael Hart for their careful reading of the manuscript. Finally I am indebted ·to Jenny Kenyon for her excellent typing of the work. Part One THE CONCEPT OF EXCITABILITY INTRODUCTION 1 1.1 The Excitable Tissues living organisms are able to respond to changes in their environment.
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
This is an admirably concise and clear guide to fundamental concepts in physiology relevant to clinical practice. It covers all the body systems in an accessible style of presentation. Bulleted checklists and boxed information provide an easy overview and summary of the essentials. By concentrating on the core knowledge of physiology, it will serve as a useful revision aid for all doctors striving to achieve postgraduate qualification, and for anyone needing to refresh their knowledge base in the key elements of clinical physiology. The author's own experience as an examiner at all levels has been distilled here for the benefit of postgraduate trainees and medical and nursing students.
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Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.
Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.