Download Free Mechanism Of Tumor Growth In Crowngall Book in PDF and EPUB Free Download. You can read online Mechanism Of Tumor Growth In Crowngall and write the review.

Agrobacterium is a plant pathogen which causes the “crown-gall” disease, a neoplastic growth that results from the transfer of a well-defined DNA segment (“transferred DNA”, or “T-DNA”) from the bacterial Ti (tumor-inducing) plasmid to the host cell, its integration into the host genome, and the expression of oncogenes contained on the T-DNA. The molecular machinery, needed for T-DNA generation and transport into the host cell and encoded by a series of chromosomal (chv) and Ti-plasmid virulence (vir) genes, has been the subject of numerous studies over the past several decades. Today, Agrobacterium is the tool of choice for plant genetic engineering with an ever expanding host range that includes many commercially important crops, flowers, and tree species. Furthermore, its recent application for the genetic transformation of non-plant species, from yeast to cultivated mushrooms and even to human cells, promises this bacterium a unique place in the future of biotechnological applications. The book is a comprehensive volume describing Agrobacterium's biology, interactions with host species, and uses for genetic engineering.
The broad host range pathogenic bacterium Agrobacterium tumefaciens has been widely studied as a model system to understand horizontal gene flow, secretion of effector proteins into host cells, and plant-pathogen interactions. Agrobacterium-mediated plant transformation also is the major method for generating transgenic plants for research and biotechnology purposes. Agrobacterium species have the natural ability to conduct interkingdom genetic transfer from bacteria to eukaryotes, including most plant species, yeast, fungi, and even animal cells. In nature, A. tumefaciens causes crown gall disease resulting from expression in plants of auxin and cytokinin biosynthesis genes encoded by the transferred (T-) DNA. Gene transfer from A. tumefaciens to host cells requires virulence (vir) genes that reside on the resident tumor-inducing (Ti) plasmid. In addition to T-DNA, several Virulence (Vir) effector proteins are also translocated to host cells through a bacterial type IV secretion system. These proteins aid in T-DNA trafficking through the host cell cytoplasm, nuclear targeting, and T-DNA integration. Genes within native T-DNAs can be replaced by any gene of interest, making Agrobacterium species important tools for plant research and genetic engineering. In this research topic, we provided updated information on several important areas of Agrobacterium biology and its use for biotechnology purposes.
Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume, all aspects of the diagnosis, histopathology, genetics and treatment of retinoblastoma are discussed in detail.
Plants and animals have evolved ever since their appearance in a largely microbial world. Their own cells are less numerous than the microorganisms that they host and with whom they interact closely. The study of these interactions, termed microbial symbioses, has benefited from the development of new conceptual and technical tools. We are gaining an increasing understanding of the functioning, evolution and central importance of symbiosis in the biosphere. Since the origin of eukaryotic cells, microscopic organisms of our planet have integrated our very existence into their ways of life. The interaction between host and symbiont brings into question the notion of the individual and the traditional representation of the evolution of species, and the manipulation of symbioses facilitates fascinating new perspectives in biotechnology and health. Recent discoveries show that association is one of the main properties of organisms, making a more integrated view of biology necessary. Microbial Symbioses provides a deliberately "symbiocentric outlook, to exhibit how the exploration of microbial symbioses enriches our understanding of life, and the potential future for this discipline. - Offers a concise summary of the most recent discoveries in the field - Shows how symbiosis is acquiring a central role in the biology of the 21st century by transforming our understanding of living things - Presents scientific issues, but also societal and economic related issues (biodiversity, biotechnology) through examples from all branches of the tree of life