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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference
Examining the role of engineering in delivery of quality consumer products, this expansive resource covers the development and design of procedures, equipment, and systems utilized in the production and conversion of raw materials into food and nonfood consumer goods. With nearly 2000 photographs, figures, tables, and equations including 128 color figures the book emphasizes and illustrates the various engineering processes associated with the production of materials with agricultural origin. With contributions from more than 350 experts and featuring more than 200 entries and 3600 references, this is the largest and most comprehensive guide on raw production technology.
This book is based on a 1981 German language edition published by Springer Verlag, Vienna, under the title Bioprozesstechnik. Philip Manor has done the translation, for which I am deeply grateful. This book differs from the German edition in many ways besides language. It is substantially enlargened and updated, and examples of computer simula tions have been added together with other appendices to make the work both more comprehensive and more practical. This book is the result of over 15 years of experience in teaching and research. It stems from lectures that I began in 1970 at the Technical University of Graz, Austria, and continued at the University of Western Ontario in London, Canada, 1980; at the Free University of Brussels, 1981; at Chalmers Technical University in G6teborg, Sweden; at the Academy of Sciences in lena, East Germany; at the "Haus der Technik" in Essen, West Germany, 1982; at the Academy of Science in Sofia, Bulgaria; and at the Technical University of Delft, Netherlands, 1986. The main goals of this book are, first, to bridge the gap that always exists between basic principles and applied engineering practice, second, to enhance the integration between biological and physical phenomena, and, third, to contribute to the internal development of the field of biotechnology by describing the process-oriented field of bioprocess technology.
This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. ​
Since fossil fuels suffer from dangerous side effects for the environment and their resources are limited, bioenergy attracted many attentions in various aspects as an alternative solution. Therefore, increasing number of researches are conducted every year and the processes updated frequently to make them more economic and industrially beneficial. Advances in Bioenergy and Microfluidic Applications reviews recent developments in this field and covers various advanced bio-applications, which rarely are reviewed elsewhere. The chapters are started from converting biomass to valuable products and continues with applications of biomass in water-treatment, novel sorbents and membranes, refineries, microfluidic devices and etc. The book covers various routes for gaining bioenergy from biomass. Their composition, carbon contents, heat production capacities and other important factors are reviewed in details in different chapters. Then, the processes for upgrading them directly and indirectly (using metabolic engineering and ultrasonic devices) to various fuels are explained. Each process is reviewed both technically and economically and the product analysis is given. Besides, the effect of various catalysts on increasing selectivity and productivity are taken into account. Biofuels are compared with fossil fuels and challenges in the way of bioenergy production are explained. Moreover, advanced bio-applications in membranes, adsorption, waste water treatment, microfluidic devices and etc. are introduced. This book provides a good insight about such bioprocesses and microfluidics devices for researchers, students, professors and related departments and industries that care about energy resources and curious about recent advances in related methods and technologies. Despite other books which review biomass chemistry and conversion, the current book emphasize on the application of biomass in the mentioned areas. Therefore, one can gain a better and more comprehensive insight by reading the book. - Describes energy production from biomass, biomass conversion, their advantages and limitations - Describes the application of biomass in membranes, sorbents, water-treatment, refineries, and microfluidic devices - Offers a future outlook of bioenergy production and possibility to apply in the industries
Today, biochemical process industry demands fast and economic processes for the partitioning and purification of biomolecules that give high yield and high purity of the product. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification. The aim of this comprehensive text is to provide an insightful overview of the whole aspects of downstream processing for biochemical product recovery. Intended for undergraduate and postgraduate students of biotechnology and chemical engineering, this self-contained text includes the chapters based on the recent developments in the industry and academics. It covers the importance of the downstream processing in terms of its relevancy to modern days ever-changing consumer needs, process design criteria relevance to set objectives, and physicochemical factors that help to formulate the strategy to develop a configuration among the raw material, methodology and instruments. This overview is followed by different downstream processing steps. The text concludes with the discussion on stabilization of the product to improve the shelf life of the product. Key Features Includes detailed biological, mathematical, chemical and physical aspects of downstream processing. Distinguishes downstream processing from analytical bioseparation. Contains numerous illustrations and solved problems.