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In this sweet small-town romance, a man gets a second chance at happiness with the woman he's loved for years after she returns home to the coastal island of South Carolina--sure to capture the hearts of Jill Shalvis and Debbie Macomber fans. Love is the sweetest way home . . . After a taste of Broadway stardom and a failed marriage, Francine Tanner is rebuilding her life back home on Cavanaugh Island. She's done with acting-and anyone who isn't genuine about real life and true feelings. But the mysterious newcomer who's bought land outside her hometown of Sanctuary Cove is as down-to-earth as he is handsome . . . and he may be her second chance for the real thing. Keaton Grace has had a crush on glamour-girl Francine Tanner for years. He can't believe his luck that she lives in the same small town where he's developing his new film studio. He just has to convince his favorite star to return to the spotlight. Yet the more time they spend together, the more he realizes the smart, funny, sexy woman she is in real life is far better than any role he envisioned. Now what he wants most is to heal her pain-and prove their attraction could be more powerful than anything they ever imagined . . . "The kind of place you visit and never want to leave." --Hope Ramsay, bestselling author of Last Chance Beauty Queen,on Sanctuary Cove
#1 New York Times Bestseller Magnolia Table is infused with Joanna Gaines' warmth and passion for all things family, prepared and served straight from the heart of her home, with recipes inspired by dozens of Gaines family favorites and classic comfort selections from the couple's new Waco restaurant, Magnolia Table. Jo believes there's no better way to celebrate family and friendship than through the art of togetherness, celebrating tradition, and sharing a great meal. Magnolia Table includes 125 classic recipes—from breakfast, lunch, and dinner to small plates, snacks, and desserts—presenting a modern selection of American classics and personal family favorites. Complemented by her love for her garden, these dishes also incorporate homegrown, seasonal produce at the peak of its flavor. Inside Magnolia Table, you'll find recipes the whole family will enjoy, such as: Chicken Pot Pie Chocolate Chip Cookies Asparagus and Fontina Quiche Brussels Sprouts with Crispy Bacon, Toasted Pecans, and Balsamic Reduction Peach Caprese Overnight French Toast White Cheddar Bisque Fried Chicken with Sticky Poppy Seed Jam Lemon Pie Mac and Cheese Full of personal stories and beautiful photos, Magnolia Table is an invitation to share a seat at the table with Joanna Gaines and her family.
Celeste Graves was born in Magnolia, Texas August 30, 1919. She graduated from high school in 1935 at the age of 15. There were only eight in her graduating class. She left Magnolia for periods of time for college, World War II, and the Korean War. Her husband was a radioman in the U. S. Navy and they lived in various areas of California. They decided they wanted to raise their children in the country, thus the move back to Magnolia. During World War II she was a dispatcher for the Civilian Pilot Training Program for Aviation Enterprises at Municipal Airport. They were awarded the contract to train young ladies to ferry airplanes during the war to relieve male pilots for overseas duty. In June 1952 Celeste began her career as a superintendent's secretary for the Magnolia Independent School District. She worked in that capacity for 34 years, retiring in 1985. Since retiring she has continued to work half-time for the district. She is an active member of the Magnolia Beautification/Historical Committee serving as Secretary/Treasurer for the past ten years.
Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.