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From the day that Paul Ehrlich hailed his newly discovered treatment for syphilis as the magic bullet, antibiotics have transformed medical practice. They are considered one of the miracle drugs of the 20th century. However, the massive and increasing misuse of these agents is More...causing a problem of resistance that may prove to be one of the greatest threats to health in the 21st century. Magic Bullets, Lost Horizons aims to put some of the media sensationalism into perspective. It examines not only the development of modern antibiotics but also the obstacles faced during application of the drugs and their expected efficacy in the future.
This encyclopedia offers an interdisciplinary approach to studying science and technology within the context of world history. With balanced coverage, a logical organization, and in-depth entries, readers of all inclinations will find useful and interesting information in its contents. Science and Technology in World History takes a truly global approach to the subjects of science and technology and spans the entirety of recorded human history. Topical articles and entries on the subjects are arranged under thematic categories, which are divided further into chronological periods. This format, along with the encyclopedia's integrative approach, offers an array of perspectives that collectively contribute to the understanding of numerous fields across the world and over eras of development. Entries cover discussions of scientific and technological innovations and theories, historical vignettes, and important texts and individuals throughout the world. From the discovery of fire and the innovation of agricultural methods in China to the establishment of surgical practices in France and the invention of Quantum Theory, this encyclopedia offers comprehensive coverage of fascinating topics in science and technology through a straightforward, historical lens.
The twentieth century witnessed the greatest changes in technology and science that humans have ever witnessed. These occurred rapidly and affected such a broad range of people. Scientists, inventors, and engineers built upon the great inventions of the 19th century to expand the reach of modern technology - for a citizen in 1900, communication, transportation, and agricultural was still primarily local activities; by 2000, an American citizen was part of an interconnected global community. These developments in science and technology were also important in the social and cultural changes of the period. The Great Depression, the World Wars and Cold War, the civil rights and women's rights movements - all were greatly impacted by the rapid scientific and technological advancements in the universities and industry.
This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.
Designed for survey courses in the field A History of Medicine presents a wide-ranging overview for those seeking a solid grounding in the medical history of Western and non-Western cultures. Invaluable to instructors promoting the history of medicine in pre-professional training, and stressing major themes in the history of medicine, this third edition continues to stimulate further exploration of the events, methodologies, and theories that have shaped medical practices in decades past and continue to do so today.
In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.
In June 1941 a pair of British scientists boarded a plane for America with World War II raging all around them. They carried a precious commodity—penicillin—and the knowledge that it would change history. Once the U.S. government had been debriefed, the Office of Science Research and Development, in conjunction with British counterparts, assumed control, and penicillin became a top-secret matter of national security, second in importance only to the atomic bomb. In Cold War Resistance Marc Landas uncovers the dark history behind the discovery, production, and distribution of penicillin and other antibiotics. In 1949 the United States embargoed any material deemed of “strategic importance,” including antibiotics, from going to Communist countries, effectively shutting off the Soviet Union from a modern medical miracle. The Soviets responded by creating satellite antibiotic factories in Warsaw Pact countries that produced subpar antibiotics, which soon led to antibiotic resistance. Today, the number of effective antibiotics available is dwindling, and the state of antibiotic resistance is worsening. The Cold War played a critical role in fostering this resistance, as Landas argues in this pathbreaking history of the international struggle over antibiotics.
COVID-19 is the biggest public health and economic disaster of our time. It has posed the same threat across the globe, yet countries have responded very differently and some have clearly fared much better than others. Peter Baldwin uncovers the reasons why in this definitive account of the global politics of pandemic. He shows that how nations responded depended above all on the political tools available - how firmly could the authorities order citizens' lives and how willingly would they be obeyed? In Asia, nations quarantined the infected and their contacts. In the Americas and Europe they shut down their economies, hoping to squelch the virus's spread. Others, above all Sweden, responded with a light touch, putting their faith in social consensus over coercion. Whether citizens would follow their leaders' requests and how soon they would tire of their demands were crucial to hopes of taming the pandemic.
This book is a highly readable and entertaining account of the co-evolution of the patent system and the life science industries since the mid-19th century. The pharmaceutical industries have their origins in advances in synthetic chemistry and in natural products research. Both approaches to drug discovery and business have shaped patent law, as have the lobbying activities of the firms involved and their supporters in the legal profession. In turn, patent law has impacted on the life science industries. Compared to the first edition, which told this story for the first time, the present edition focuses more on specific businesses, products and technologies, including Bayer, Pfizer, GlaxoSmithKline, aspirin, penicillin, monoclonal antibodies and polymerase chain reaction. Another difference is that this second edition also looks into the future, addressing new areas such as systems biology, stem cell research, and synthetic biology, which promises to enable scientists to “invent” life forms from scratch.
Learn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies. In this fascinating book, you'll discover: An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.