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H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
From the New York Times bestselling author of the Thursday Next series comes a “laugh-out-loud funny” (Los Angeles Times) and “brilliantly original” (Booklist, starred review) novel of a man attempting to navigate a color-coded world. “A rich brew of dystopic fantasy and deadpan goofiness.”—The Washington Post Welcome to Chromatacia, where the Colortocracy rules society through a social hierarchy based on one’s limited color perception. In this world, you are what you can see. Eddie Russet wants to move up. When he and his father relocate to the backwater village of East Carmine, his carefully cultivated plans to leverage his better-than-average red perception and marry into a powerful family are quickly upended. Eddie must content with lethal swans, sneaky Yellows, inviolable rules, an enforced marriage to the hideous Violet deMauve, and a risky friendship with an intriguing Grey named Jane who shows Eddie that the apparent peace of his world is as much an illusion as color itself. Will Eddie be able to tread the fine line between total conformity—accepting the path, partner, and career delineated by his hue—and his instinctive curiosity that is bound to get him into trouble?
Karl Jaspers, who died in 1969, had a profound impact on 20th-century theology and philosophy. His central thesis called for, among other things, a de-centering of philosophy from its Eurocentric roots and a renewal of its dialogue with other traditions, especially Asian ones. This collection of essays includes unpublished work by Jaspers himself as well as testimonies to his life and career by colleagues, associates, and translators, some of who knew Jaspers personally. Readers will also find commentary and interpretation by researchers who have explored Jaspers’ work for decades, and a biographical account of Jaspers’ student Leonard Ehrlich, who handled much of Jaspers’ English translation. The book interrogates Jaspers’ conceptions of ‘philosophical faith’, his philosophy of communication, and the prospects for world philosophy in the future. Focusing on philosophical faith, it assesses Jaspers’ interpretations of key philosophers such as Kant, Hegel, Schelling, Kierkegaard, Nietzsche, and Rosenzweig, as well as examining his personal relationships with Bultmann and Heidegger. Contributors also look at Jaspers’ philosophies of religion and history, his hypothesis of the ‘axial age’ (Achsenzeit), and his contributions to metaphysics, periechontology, and economics. Finally, chapters cover Jaspers’ philosophy of communication and world history. The latter are informed by a burgeoning interest in Kantian ‘Freiheitphilosophie’ that influenced Jaspers, as well as concerns over the future of humanity. These concerns in part account for Jaspers’ growing popularity in the Middle East, Eastern Europe, Central/South America, and Asia. Also included are lucid clarifications of the difference between religious and philosophical faith, and the relevance of certainty, trust, and communication for a future of mankind. Trained as a psychiatrist, Jaspers practiced this profession before becoming a philosopher and thus had a keen insight into the workings of the human mind even as he challenged the philosophical establishment of his time. It is perhaps this depth to his background that adds to the contemporary relevance of his work.
In order to keep up with the constant changes in technology, business have adopted supply chain management to improve competitive strategies on a strategic and operational level. Supply Chain Management: Concepts, Methodologies, Tools, and Applications is a reference collection which highlights the major concepts and issues in the application and advancement of supply chain management. Including research from leading scholars, this resource will be useful for academics, students, and practitioners interested in the continuous study of supply chain management and its influences.
This book presents an original approach to the study of psychiatry that is based on a justified epistemological position, which demands that both the natural and the human/social sciences are necessary in developing our understanding. Psychiatry as a medical specialism was constructed in the nineteenth century through the interplay of both the natural sciences and the human/social sciences. This interplay has created a hybrid discipline that spans biological and socio-cultural-historical domains, which has raised challenges for its understanding and research. This book focuses on one of the principal challenges – how can we explore mental symptoms and mental disorders as complexes of neurobiology on the one hand and meaning on the other? The chapters in this book, dedicated to Germán E Berrios, founder of the Cambridge school of psychopathology, tackles distinctive aspects of psychopathology or related areas. By means of a combination of approaches, chapters seek to unfold another element in our understanding of this field as well as raise new directions for its further study. Rethinking Psychopathology is a valuable resource for clinical psychologists and psychotherapists, psychological researchers, historians of psychology, cultural psychologists, critical psychologists, social scientists, philosophers of psychology, and philosophers of science.
This textbook aims to raise teachers’ language awareness, to emphasise the importance of language and communication in enabling young people to reach their potential, and to develop their knowledge of how language and communication function in educational environments as well as outside. Laid out in a clear five-unit structure, and complemented by a range of classroom activities, reflective exercises, and case study examples from around the world, this book addresses the need for teachers to become more linguistically aware and sensitive in an accessible and reader-friendly way. It is an essential resource for pre-service and in-service teachers working with a range of age groups across the curriculum.
This volume is based on selected and updated papers from the symposium on "Basic Mechanisms of the EEG," which was held under the sponsor ship of the German EEG Society in Hamburg on September 28-29, 1990. The intention of this symposium was to relate recent experimental, clini cal, and neuropathological data on the basic mechanism that underlie the EEG. Although we know much about these mechanisms, there is still much more to be learned. The symposium was partly the continuation of an earlier symposium on "Origin of Cerebral Field Potentials" held in 1979 in Munster under the leadership of one of the present editors (E. -J. Speckmann) and H. Caspers. The present work combines new experimental and clinical results with state-of-the-art reports giving excellent general views. The first chapter presents a historical survey of the roots of current developments in neu rophysiology. It seems that in the near future we may decipher the EEG, which we have considered up to now somewhat as a cryptogram (chap ter 2). After chapter 3-a chapter concerned with more general points of the generation of cortical field potentials-chapters 4, 5, and 6 deal with several aspects and models of interactions and rhythms of cortical neurons. The role of glial cells in cortical electrical field generation is considered in chapter 7. Chapter 8 emphasizes the significance of brain metabolism.