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Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Seeds provide more than half of the world's intake of dietary protein and energy and thus are of immense economic, cultural and nutritional importance. Proteins can account for up to 40% of the dry weight of various types of seeds, thereby making a large contribution to the nutritional quality and processing properties of seeds. It is, therefore, not surprising that seed proteins were among the first plant components to be systematically studied, some 250 years ago, and have been a major focus of research over the past 100 years. The properties and behaviour of seed proteins pervade modem life in numerous ways. For example, legume and cereal proteins are used'in the production of a wide range of meat-free foods; the process of bread-making is dep~ndent on the physical chemical properties of wheat seed proteins; and in developed, as well as developing, countries, nutritional deficiencies among vegetarian diets are avoided through balancing legume and cereal seeds as sources of dietary proteins. Understanding seed proteins, in order to improve their composition and properties and to increase their concentrations, will thus continue to be an important research objective for the future. The present volume represents the culmination of a long-discussed plan of the editors, to bring together the best international authorities in order to compile a definitive monograph on biological, biochemical, molecular and genetic aspects of seed proteins.
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Developments in Plant Genetics and Breeding, 1A: Isozymes in Plant Genetics and Breeding, Part A focuses on the advancements in the processes, methodologies, and approaches involved in the study of isozymes, including its role in plant genetics and breeding. The selection first elaborates on the historical perspectives of plant isozymes, plant genetics, and isozyme systems to study gene regulation during development. Discussions focus on the use of isozyme and similar comparisons to study differential gene regulation, gene preservation, dissemination of cultivars, propagation of cultivars and breeding lines, and studies on the effect of viral infection and hormones on isozyme expression. The text then examines allozymes in gene dosage studies, gene mapping, and plastid isozymes. The manuscript takes a look at the genetics of mitochondrial isozymes, evolution of plant isozymes, and detection of somatic variation. Topics include evolution of isozymes in plants, generation of isozymes, glutamate dehydrogenase, glutamate-oxaloacetate transaminase, and malate dehydrogenase. The text also ponders on enzyme activity staining, isozymic variation and plant breeders' rights, genetic purity of commercial seed lots, and use of isozymes in plant disease research. The selection is a valuable reference for researchers interested in the role of isozymes in plant genetics and breeding.
The development of resistance to pesticides is generally acknowledged as one of the most serious obstacles to effective pest control today. Since house flies first developed resistance to DDT in 1946, more than 428 species of arthropods, at least 91 species of plant pathogens, five species of noxious weeds and two species of nematodes were reported to have developed strains resistant to on~ or more pesticides. A seminar of U. S. and Japanese scientists was held in Palm Springs, California, during December 3-7, 1979, under the U. S. -Japan Cooperative Science Program, in order to evaluate the status of research on resistance and to discuss directions for future emphasis. A total of 32 papers were presented under three principal topics: Origins and Dynamics of Resistance (6), Mechanisms of Resistance (18), and Suppression and Management of Resistance (8). The seminar was unique in that it brought together for the first time researchers from the disciplines of entomology, plant pathology and weed science for a comprehensive discussion of this common problem. Significant advances have been identified in (a) the development of methods for detection and monitoring of resistance in arthropods (electrophoresis, diagnostic dosage tests) and plant pathogens, (b) research on biochemical and physiological mechanisms of resis tance (cytochrome p450, sensitivity of target site, gene regulation), (c) the identification and quantification of biotic, genetic and operational factors influencing the evolution of resistance, and (d) the exploration of pest management approaches incorporating resis tance-delaying measures.
These Proceedings are a product of the International Workshop on Seeds held in Williamsburg, Virginia, USA, at the College of William and Mary, during the week of August 6-11, 1989. Sixty-eight participants attended. The location provided a scenic and historical setting for the excellent work presented. Good facilities and amenities also contributed to the success of the meeting. The Proceedings present the substance of the main lectures given at this meeting. In addition, there were 29 brief paper presentations and 30 poster presentations which have been summarized in abstract form in a separate publication. This meeting represents the third such meeting of a diverse group of scientists interested in the behavior of seeds, both in an agricultural sense and as tools for the advancement of more particular s~bject matter. The first meeting was held in Jerusalem, Israel in 1980 and the second in Wageningen, The Netherlands in 1985. A fourth meeting is being planned. The Editor and Organizer wishes to thank not only the contributors to this volume for their efforts but also all the other participants whose combined efforts made this meeting a great success.