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The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
This book presents closed-loop blood glucose control in a simple manner, which includes the hardware and "software" components that make up the control system. It provides examples on how mathematical models are formulated as well as the control algorithms that stem from mathematical exercises. The book also describes the basic physiology of blood glucose regulation during fasting and meal from a functional level.
This book covers the complete gamut of neuroradiology cases, including normal anatomy, pitfalls, and artifacts across the brain and spine in a single volume, enriched with high-resolution images that support the interpretation of CT and MRI images of the brain, spine, head, and neck. It includes case studies commonly encountered in clinical practice, in addition to normal anatomy, that prepare the reader for the challenges in the clinical setting. Each case study discusses the clinical history, relevant imaging findings, differential diagnosis, and management, serving as a helpful read for trainee radiologists, neurophysicians, neurosurgeons, and CT/MRI technicians, along with physicians interested in medical imaging. Key Features Provides a succinct overview of normal variants with case studies structured into thematic chapters Serves as a basic accompaniment for radiology residents, fellows, practicing radiologists, neurophysicians, neurosurgeons, emergency medicine practitioners, trainee and practicing radiographers, and those studying for Board exams Highlights the relevance of artificial intelligence in clinical practice
This important book provides a guide to the fundamentals and latest developments in smart technology for textiles and clothing. The contributors represent a distinguished international panel of experts and the book covers many aspects of cutting edge research and development.Smart fibres, fabrics and clothing starts with a review of the background to smart technology and goes on to cover a wide range of the material science and fibre science aspects of the technology including: Electrically active polymeric materials and the applications of nonionic polymer gel and elastomers for artificial muscles; Thermally sensitive fibres and fabrics; Cross-linked polyol fibrous substrates stimuli-responsive interpenetrating polymer network hydrogel; Permeation control through stimuli-responsive polymer membranes; optical fibre sensors, hollow fibre membranes for gas separation; integrating fibre-formed components into textile structures; Wearable electronic and photonic technologies; Adaptive and responsive textile structures (ARTS); Biomedical applications including the applications of scaffolds in tissue engineeringIt is essential reading for academics in textile and materials science departments, researchers, designers and engineers in the textiles and clothing product design field. Product managers and senior executives within textile and clothing manufacturing will also find the latest insights into technological developments in the field valuable and fascinating.
Written by pioneers in the field, this book covers optical, gas, taste, and other sensing systems using various kinds of polymers. It provides all the necessary background information and science to develop a basic understanding of the field, its supporting technologies, and current applications.
This major reference work, covering the important materials science area of gels, is a translation of a Japanese handbook. The three-volume set is organized to cover the following: fundamentals, functions, and environmental issues. Gels Handbook also contains an appendix, complete references, and data on gel compounds.Recently, polymer gels have attracted many scientific researchers, medical doctors, and pharmaceutical, chemical, and agricultural engineers to the rapidly growing field. Gels are considered to be one of the most promising materials in the 21st Century. They are unique in that they are soft, gentle, and can sense and accommodate environmental changes. Because of these unique characteristics gels have a huge potential in technological and medical applications. They are irreplaceable in the separation of molecules, the release of drugs, artificial skins and organs, sensors, actuators, chemical memories, and many other applications.The 21st century is also said to be the century of biotechnology, where two kinds of biopolymers play crucial roles: DNA as a bearer of geneticinformation and proteins as molecular machines. In spite of the dramatic progress in molecular biology and the Human Genome project, the basic principles behind the function and design of such polymeric machines are in the black box. Science and technologies that will emerge from those of polymer gels will shed light on such principles.Some researchers have already developed prototypes of artificial glands (pancreas), artificial muscles and actuators, and chemical sensors and molecular recovery systems using polymer gels.The Gels Handbook is an invaluable source of information on this rapidly growing field. It covers the entire area from the scientific basics to the applications of the materials. The authors are among the leading researchers, doctors, engineers, and patent officers in Japan. This book can be used as a textbook or an encyclopedia and is a must for those involved in gel research or applications. Key Features* Comprehensive coverage of a popular topic in materials science* Is the first english-language gels handbook* Includes numerous figures, tables, and photos