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A current review of basic research on Rickettsiales biology and pathogenesis in one comprehensive volume. • Details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells. • Describes the spectrum of disease caused by an infection and the role of vectors in transmission. • Discusses protective and pathologic immune responses and establishment of persistent infection. • Describes the latest developments including genomics and progress in vaccine development. • Serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
Opportunistic, intracellular bacterial infections are at the forefront of research because of the challenges they present to immunocompromised patients. In this volume, the pathogenesis and immune reaction of these intracellular infections is featured, as are the most typical problems related to antimicrobial chemotherapy, and current approaches to their solution. Individual chapters set the pace for research on pathogenic and immune reactions to such infections as, mycobacterium tuberculosis, legionella pneumophila, chlamydia trachomatis and brucella.
The Tropical Medicine Notebook is a new concept in providing a concise overview of the key topics in tropical medicine, using short notes, diagrams, maps, and tables to present the material in an accessible, engaging, memorable, and interesting way. The format is generally a page per topic, with division of each page into subsections by boxes to make it easy to find the relevant information. Cross-referencing is provided to allow quick linking between relevant sections of the book. Providing the key information in bite-size chunks, the Tropical Medicine Notebook is a useful companion to more comprehensive texts. Divided into eight sections; the first five cover infections caused by bacteria, viruses, fungi, protozoa and helminths, followed by a further three which present the topics of vector biology, disease syndromes and envenomation. Where relevant, the section is prefaced by a classification system to provide a logical overview, helping with assimilation of information and highlighting important relationships between organisms. It is an ideal learning and revision guide for students or trainees in infection, microbiology, and tropical medicine, as well as being a useful reference resource for healthcare and laboratory staff across the wide range of disciplines to which infection may present.
The book describes the different and exciting pathways which have been developed by pathogenic microbes to manage living inside host cells. It covers intracellular life styles of all relevant pathogenic but also symbiotic microorganisms with respect to the cell biology of the host-microbe interactions and the microbial adaptations for intracellular survival. It features intracellular trafficking pathways and characteristics of intracellular niches of individual microbes. The book also asks questions on the benefits for the microbe with regard to physiological needs and nutritional aspects such as auxotrophy, effects on genome sizes, and consequences for disease and host response/immunity (and the benefits for the host in the cases of symbionts). Additionally, the book includes those pathogens that are medically less important but represent distinct intracellular niches, trafficking behaviours and virulence traits. The individual chapters also point out future challenges of research for the respective organism.
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with Mycobacterium tuberculosis and M. leprae subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity the latest developments in technology, for the next steps in the study of intracellularity All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control