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Over 200 neuroscientists met at the Max-Planck-Institut fur Biophysikalische Chemie in Gottingen between April 7th-9th 1983 in order to honour a foreign member of the Institute, namely Sir John Carew Eccles, who celebrated his 80th birthday on January 27th 1983. It was a lively scientific gathering of former students, colleagues and friends of Sir John and Lady Helena. We had all come together from different parts of the world to celebrate this occasion, which gave us the wonderful chance to meet the various members of a large family, united by respect and gratitude for Sir John. The lectures were based on the many themes which have been at the centre of John Eccles' scientific zeal throughout his life. Indeed the chapter headings of this book have been taken from the book titles of Sir John's own work. We would also have liked to publish the discussions which took place after every lecture and to each of which John Eccles contributed in his usual lively manner, but editing them would not have conveyed the stimulating atmosphere, which Sir John created.
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This book is concerned with sensory cue integration both within and between sensory modalities, and focuses on the emerging way of thinking about cue combination in terms of uncertainty. These probabilistic approaches derive from the realization that our sensors are noisy and moreover are often affected by ambiguity. For example, mechanoreceptor outputs are variable and they cannot distinguish if a perceived force is caused by the weight of an object or by force we are producing ourselves. The probabilistic approaches elaborated in this book aim at formalizing the uncertainty of cues. They describe cue combination as the nervous system's attempt to minimize uncertainty in its estimates and to choose successful actions. Some computational approaches described in the chapters of this book are concerned with the application of such statistical ideas to real-world cue-combination problems. Others ask how uncertainty may be represented in the nervous system and used for cue combination. Importantly, across behavioral, electrophysiological and theoretical approaches, Bayesian statistics is emerging as a common language in which cue-combination problems can be expressed.
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.