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The pharmaceutical industry is an $837 billion a year industry that is being plagued by low R&D productivity. This decline in productivity has resulted in significant erosion of value. From December 2000 to February 2008, the top 15 pharmaceutical companies lost about $850 billion in shareholder value and their stock price fell precipitously from 32 times earnings to an average of 13 (Garnier, 2008). In an attempt to boost R&D productivity, pharmaceutical companies are jettisoning their old lumbering and bureaucratic R&D organizations for de-centralized and entrepreneurial models in a wave of organizational redesigns that is aimed at delivering innovation and creating value. In this research, I have studied this new trend in organizational redesign by finding out what went wrong with the old model, what are the drivers for change, what is the new model and what strategic imperatives are they aimed at achieving. I have undertaken this by studying the top 5 research-based pharmaceutical companies. I have used interviews and extensive secondary research to gather facts and gain insight into issues and questions mentioned above. I then used the Three Organizational Lenses Framework by (Ancona et al, 2005) to analyze the new model at play in each of the 5 companies studied and proposed recommendations going forward. I found that whilst organizational design provides strong tools, techniques and systems for enhancing R&D productivity, implementing a new organizational structure alone will not suffice. There has to be a comprehensive approach that involves structure, systems and incentives; as well as paradigm shifts in both leadership and culture.
Boosting Pharmaceutical Innovation In The Post-TRIPS Era investigates the concept of innovation and illustrates the crucial role that patent strategies play within processes of pharmaceutical innovation. Drawing on extensive country and company case studies, it identifies the key issues relevant to the revival of local pharmaceutical industries.
A number one Irish bestseller, and winner of the Popular Non-Fiction Book of the Year at the Irish Book Awards In this fascinating and thought-provoking book, Professor Luke O'Neill grapples with life's biggest questions and tells us what science has to say about them. Covering topics from global pandemics to gender, addiction to euthanasia, Luke O'Neill's easy wit and clever pop-culture references deconstruct the science to make complex questions accessible. Arriving at science's definitive answers to some of the most controversial topics human beings have to grapple with, Never Mind the B#ll*ocks, Here's the Science is a celebration of science and hard facts in a time of fake news and sometimes unhelpful groupthink. 'A celebration of scientific fact in an era characterised by nebulous subjectivity' Irish Times
This practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.
This paper presents the results of a study of the determinants of research productivity in the pharmaceutical industry. Using disaggregated, internal firm data at the research program level from ten major pharmaceutical companies, we find no evidence of increasing returns to scale at either the firm or the research program level. However our results suggest that there are three benefits to running research programs within the context of larger and more diversified R & D efforts: economies of scale arising from sharing fixed costs; economies of scope arising from the opportunity to exploit knowledge across program boundaries within the firm; and the enhanced ability to absorb internal and external spillovers. We also find that spillovers between firms may playa major role in increasing research productivity. The paper also speaks directly to the question of firm heterogeneity. A significant proportion of the "firm effect" identified in previous studies can be explained by the slowly changing composition of the research portfolio, as well as by less easily measured aspects of innovative capability.
Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher.Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.