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Immunosuppression by Progesterone in Pregnancy describes a newly discovered feto-protective mechanism resulting from the interaction of the immune and endocrine systems. As a response to antigenic stimulation by the fetus, lymphocytes of pregnant women develop non-classical progesterone receptors. Receptor binding of progesterone in the lymphocytes triggers the production of a mediator protein. Through an immunological pathway, this protein prevents abortion in murine models, and its serum concentration correlates with pregnancy outcome in humans. The regulation of these unusual receptors, as well as diagnostic and therapeutic implications of the mediator protein, are discussed. Immunologists, reproductive biologists, obstetricians, gynecologists, and other researchers studying this aspect of reproductive biology will find the book to be indispensable.
This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.
The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.
This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments.
Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. - Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus - Evaluates each immune cell type and its function during specific reproductive events - Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series
Chesley's Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley's Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia. - Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis - Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management - Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia - Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book
Thoroughly revised and now enhanced with color artwork, this new edition offers the latest information on the diagnosis and management of reproductive endocrine disorders. As an Expert Consult title, it includes convenient online access to the complete text of the book along with all of the images and references linked to Medline.
"This book contains a collection of the most recent insights regarding maternal morbidity and mortality and optimization of the care processes during acute critical illness. The volume represents a practical resource to be used in real-time by medical practitioners faced with a woman who is critically ill during pregnancy and the peripartum period. By providing concise tools for disease identifiers and management flow-charts, the Editors aimed to increase awareness and improve processes of care for this population. Many care paradigms for obstetric patients are currently unstandardized, unfocused and often do not follow a pre-determined path. Each chapter will provide the practitioner with updated information on how to identify specific critical conditions and how to manage them once they have been identified, to enhance recognition and readiness. This book should be used as a resource to improve the quality of care administered to obstetric patients, to reduce fragmented care processes and to improve interdisciplinary co-ordination and communication, with the overall aim of decreasing maternal morbidity and mortality. Therefore, this book represents an invaluable guide to specialists in critical care, anesthesia and obstetrics as well as to intensive care nurses and midwives."
Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.