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The major aim of this book is to demystify splenic pathology for nonspecialist consultants and trainees in histopathology. The interpretation of pathological changes in the human spleen provides a significant challenge to the skills of even the most highly trained histopathologists. This comprehensive account of the most important and frequently encountered pathological conditions affecting the spleen is highly illustrated in color throughout with numerous detailed macroscopic and microscopic specimens. Emphasis is placed on the importance of adequate clinical information and technical preparation of splenectomy specimens in obtaining the best possible histopathological assessment of the tissue. A systematic, analytical approach to interpretation of pathological changes is used throughout the book. This text should enable readers to feel confident in their assessment of significant processes within the spleen. This volume will serve as an illustrated atlas, bench manual, text, and reference source.
The spleen is an organ which has diverse functions including immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the normal and pathologic conditions that afflict the spleen. This extraordinary collection of high quality digital images will materially aid in continuing efforts to recognize, understand, and accurately interpret the gross and light microscopic findings in spleens.
The spleen is an organ which has diverse functions including immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the normal and pathologic conditions that afflict the spleen. This extraordinary collection of high quality digital images will materially aid in continuing efforts to recognize, understand, and accurately interpret the gross and light microscopic findings in spleens.
Contributors review the state of current knowledge and document progress in the anatomy and physiology of the spleen. Topics include: general features, pathophysiology, splenomegaly, imaging and surgery, and new trends. The role of the spleen in various diseases is clarified, among them: hypo- and h
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses. Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms. Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis. Includes 14 new chapters covering topics such autoimmune disease involving the spleen, COVID-19-related diseases, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, primary splenic mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many more. Includes approximately 2,000 high-quality clinical and histological images, gross pathology images, radiologic images, and full-color drawings to help practicing and in-training pathologists reach a confident diagnosis. Includes updated criteria, terminology, and classifications from the 2017 WHO Classification of Lymphoid Neoplasms. Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care. Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices.
This volume provides a much-needed update on imaging of the spleen, a subject that has witnessed a revival of interest in recent years owing to new insights into physiology and pathophysiology and the application of modern noninvasive imaging modalities. Introductory chapters discuss the normal anatomy and radiological appearances. Thereafter individual chapters document the imaging findings in a wide range of hematological, immunological, oncological, infectious, vascular, and systemic disorders. Splenic pathology in infancy and childhood is considered separately, and there is a chapter on interventional procedures. Informative differential diagnostic tables are also provided. This well-illustrated book will serve as an invaluable source of easily accessible information for both clinicians and radiologists.
In this thoroughly revised and updated second edition, a panel of distinguished clinical researchers from around the world takes stock of the wealth of new knowledge about the human spleen and applies it to the pathology and treatment of splenic diseases. This much enriched understanding encompasses the spleen's complex role in immunological defense, the recently defined function of particulate filtration by the spleen, and the structural basis for the functions of the spleen, most particularly the microvasculature around which it is organized. Among the diseases and disorders of the spleen considered in detail are splenomegaly, the consequences and management of hyper- and hyposplenism, and "dilutional anemia." Recent advances in splenic surgery are also reviewed, especially those techniques intended to preserve at least partial function while removing the greater part of the organ.