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If people are endowed with a "number instinct" similar to the "language instinct" -- as recent research suggests -- then why can't everyone do math? In The Math Gene, mathematician and popular writer Keith Devlin attacks both sides of this question. Devlin offers a breathtakingly new theory of language development that describes how language evolved in two stages and how its main purpose was not communication. Devlin goes on to show that the ability to think mathematically arose out of the same symbol-manipulating ability that was so crucial to the very first emergence of true language. Why, then, can't we do math as well as we speak? The answer, says Devlin, is that we can and do -- we just don't recognize when we're using mathematical reasoning.
In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and break­ing, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the fric­tion in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
The final novel of one of America’s most beloved writers—a tale of degeneration, corruption, and spiritual crisis A Penguin Classic In awarding John Steinbeck the 1962 Nobel Prize in Literature, the Nobel committee stated that with The Winter of Our Discontent, he had “resumed his position as an independent expounder of the truth, with an unbiased instinct for what is genuinely American.” Ethan Allen Hawley, the protagonist of Steinbeck’s last novel, works as a clerk in a grocery store that his family once owned. With Ethan no longer a member of Long Island’s aristocratic class, his wife is restless, and his teenage children are hungry for the tantalizing material comforts he cannot provide. Then one day, in a moment of moral crisis, Ethan decides to take a holiday from his own scrupulous standards. Set in Steinbeck’s contemporary 1960 America, the novel explores the tenuous line between private and public honesty, and today ranks alongside his most acclaimed works of penetrating insight into the American condition. This Penguin Classics edition features an introduction and notes by leading Steinbeck scholar Susan Shillinglaw. For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.
The e-mail Danny and Allison read on their new computer in 1996 looks no different from the millions of others received by Web users around the world, with one glaring exception--it was sent by their dads who died during the 1970s. While residing in the afterworld at an amenity-laden paradise called Midway Manor, guitar-strumming Mickey Parks and piano-playing Lloyd Wallace monitor and manipulate the lives of their adult children on earth from the mid-'70s through the 1990s. Tampering with the facility's sophisticated computer, the dads thrust Mickey's daughter Allison and Lloyd's son Danny into a passionate but sometimes stormy relationship-a relationship steeped in Danny's heavy drinking and entangled in the often-zany world of men's adventure magazine publishing. After carefully implementing a plan to send their son and daughter a gift of knowledge that could enrich their lives forever, the dads' brief contact is cut short. They are banished to another destination in the afterworld, but not before they impart indisputable proof of life after death--and unwittingly put Danny's and Allison's earthbound lives on the line.
Now in its second edition Maritime Economics provides a valuable introduction to the organisation and workings of the global shipping industry. The author outlines the economic theory as well as many of the operational practicalities involved. Extensively revised for the new edition, the book has many clear illustrations and tables. Topics covered include: * an overview of international trade * Maritime Law * economic organisation and principles * financing ships and shipping companies * market research and forecasting.
In this collaboration with Roger Zelazny, an armless and legless painter must undertake a pilgrimage through a nuclear war-ravaged America in a search for the God of Wrath, whose picture he has been commissioned to paint.
Altered reality, genetic enhancement and drugs combine to create one of the most popular and enduring science fiction novels from award-winning novelist Philip K. Dick.
This introduction to Atomic and Molecular Physics explains how our present model of atoms and molecules has been developed over the last two centuries both by many experimental discoveries and, from the theoretical side, by the introduction of quantum physics to the adequate description of micro-particles. It illustrates the wave model of particles by many examples and shows the limits of classical description. The interaction of electromagnetic radiation with atoms and molecules and its potential for spectroscopy is outlined in more detail and in particular lasers as modern spectroscopic tools are discussed more thoroughly. Many examples and problems with solutions are offered to encourage readers to actively engage in applying and adapting the fundamental physics presented in this textbook to specific situations. Completely revised third edition with new sections covering all actual developments, like photonics, ultrashort lasers, ultraprecise frequency combs, free electron lasers, cooling and trapping of atoms, quantum optics and quantum information.