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Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Handbook IMCI

World Health Organization. Department of Child and Adolescent Health and Development

Published: 2005

Total Pages: 210


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This handbook gives a detailed explanation of the WHO/UNICEF guidelines for the integrated management of childhood illness (IMCI). The guidelines set out simple and effective methods for the prevention and management of the leading causes of serious illness and mortality in young children. They promote evidence-based assessment and treatment using a syndromic approach that supports the rational, effective and affordable use of drugs. The handbook gives an overview of the IMCI process and includes technical guidelines to assess and classify a sick young infant aged from one week up to two months, and a sick young child aged two months to five years; as well as guidance on how to identify treatment; communicate and counsel; and give follow-up care.
Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.
Find fast answers to inform your daily diagnosis and treatment decisions! Ferri’s Clinical Advisor 2021 uses the popular "5 books in 1" format to deliver vast amounts of information in a clinically relevant, user-friendly manner. This bestselling reference has been significantly updated to provide you with easy access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, clinical algorithms, laboratory tests, and clinical practice guidelines—all carefully reviewed by experts in key clinical fields. Extensive algorithms, along with hundreds of new figures and tables, ensure that you stay current with today's medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic rhinosinusitis, subclinical brain infarction, reflux-cough syndrome, radiation pneumonitis, catatonia, end-stage renal disease, and genitourinary syndrome of menopause, among others. Includes new appendices covering common herbs in integrated medicine and herbal activities against pain and chronic diseases; palliative care; and preoperative evaluation. Offers online access to Patient Teaching Guides in both English and Spanish.
A new multimedia e-dition package includes the book and CD-ROM plus access to the continuously updated website! The website (http://www.criticalcaretext.com) also offers links to important websites, calculators, the full text online, and all the illustrations--downloadable for presentations. A completely new editorial team presents the radical revision to this leading critical care text, previously edited by Shoemaker et al. Today's best coverage of both adult and pediatric critical care, with contributions from an impressive roster of world experts. In addition to numerous new chapters and many extensively rewritten ones, it features a completely new section on commonly encountered problems and a new, more user-friendly organization. Covers both adult and pediatric critical care. Features the authority of the top names in critical care from around the world, including an outstanding new editorial team as well as authors who are among the most highly respected researchers, instructors, and clinicians in the field. Offers a brand-new section that provides quick access to practical guidance on the problems most frequently encountered in the ICU. Explores hot new topics such as Inter- and Intra-Hospital Transport, Disaster Medicine for the ICU Physician, and Teaching Critical Care. Provides a new, more user-friendly organization. Presents only the most essential references within the text, with the rest provided on the enclosed CD-ROM. Is available in a multimedia package that combines the book with access to a fully searchable, continuously updated web site!. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets
Accompanying CD-ROM contains: contents of book; continuous updates; slide image library; references linked to MEDLINE; pediatric guidelines; case studies; review questions.

Red Book

American Academy of Pediatrics. Committee on Infectious Diseases

Published: 2003

Total Pages: 966


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The 2003 Red Book, 26th Edition advances the Red Book's mission for the 21st century, with the most current information on clinical manifestations, etiology, epidemiology, diagnosis, and treatment of more than 200 childhood infectious diseases. Developed with the assistance and advice of hundreds of physician contributors from across the country, the new edition contains a host of significant revisions, updates, and additions to its authoritative content. Includes active and passive immunization, recommendations for care of children in special circumstances, summaries of infectious diseases, antimicrobial agents and related therapy, antimicrobial prophylaxis, and useful appendices.
In this online Open Access book on "Human RSV Infections", several distinguished authors contribute their experience in respiratory syncytial virology. A major focus lies on the fascinating pathophysiology of RSV and represents recent and actual work on different mechanisms involved in the complex pathogenesis of the virus. The second section elucidates epidemiologic and diagnostic aspects of RSV infection covering a more clinical view of RSV disease. At last, treatment modalities including the search for a vaccine that is still not in sight are discussed and conclude this book, thus building up a circle that runs from experimental models of RSV related lung disease over clinical aspects of disease to the latest news of therapeutic and prophylactic approaches to human RSV infection.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS