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All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field.
Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.
The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms.Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. - Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment - Discusses novel approaches to study parasite infection and treatment - Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Featuring the work of several world authorities, this volume places primary emphasis on the mechanism of parasite produced changes in the immune response (i.e. immunosuppression). The text covers parasitic diseases on which the World Health Organization has aggressively promoted research through its Program on Research and Training In Tropical Diseases. Chapters cover parasitic diseases such as malaria, American trypanosomiasis (Chagas' disease), African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and onchocerciasis. Also included are discussions of toxoplasmosis and amebiasis. The material is drawn from the body of literature that has been rapidly accumulating for the last 15 years. An important feature of this text is that the contributors first outline existing knowledge about the immunology of each infection, thereby enabling the reader to more easily appreciate why and how the immunological alterations that accompany a disease are important, and then, to review the postulated mechanisms for such alterations. Consequently, the impact that each parasitic infection has on the immune system is always described in the "heart" of each chapter rather than at the beginning.
The theme of this volume is to discuss Eco-evolutionary Dynamics. - Updates and informs the reader on the latest research findings - Written by leading experts in the field - Highlights areas for future investigation