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This comprehensive introduction to the field of human biology covers all the major areas of the field: genetic variation, variation related to climate, infectious and non-infectious diseases, aging, growth, nutrition, and demography. Written by four expert authors working in close collaboration, this second edition has been thoroughly updated to provide undergraduate and graduate students with two new chapters: one on race and culture and their ties to human biology, and the other a concluding summary chapter highlighting the integration and intersection of the topics covered in the book.
Providing essential reading for medical, veterinary and biological science students, and students of physiology and trainees in obstetrics and gynaecology, the seventh edition of Essential Reproduction offers an up-to-date account of the fundamentals of reproduction within the context of cutting-edge knowledge and examples of its application. It provides a multidisciplinary approach integrating physiology, genetics, behaviour, anatomy and clinical science, to give thorough coverage of the study of mammalian reproduction. Essential Reproduction is now accompanied by the Wiley E-Text: Powered by VitalSource, and includes: The latest on conceptual, informational and applied aspects of reproduction A new structure offering a more logical approach to study and revision Expanded further reading suggestions to support research A companion website at www.essentialreproduction.com features all of the images from the book to download – perfect for instructor and student support. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.
Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Basics in Human Evolution offers a broad view of evolutionary biology and medicine. The book is written for a non-expert audience, providing accessible and convenient content that will appeal to numerous readers across the interdisciplinary field. From evolutionary theory, to cultural evolution, this book fills gaps in the readers' knowledge from various backgrounds and introduces them to thought leaders in human evolution research. - Offers comprehensive coverage of the wide ranging field of human evolution - Written for a non-expert audience, providing accessible and convenient content that will appeal to numerous readers across the interdisciplinary field - Provides expertise from leading minds in the field - Allows the reader the ability to gain exposure to various topics in one publication
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.
4. Auflage dieses Klassikers und führenden Referenzwerks aus dem Bereich Sport-, Bewegungs- und Leistungspsychologie Die vollständige neue Ausgabe des Handbook of Sports Psychology, jetzt in 2 Bänden und mit unzähligen neuen Kapitel renommierter Wissenschaftler des Fachgebiets, greift auf eine Riege von Experten und Wissenschaftlern zurück, die ihr Wissen nach dem neuesten Forschungsstand in diesem gründlichen und zugänglichen Referenzwerk zusammenfassen. Die Publikation wird auch von der International Society of Sport Psychology unterstützt und ist eine unschätzbare Quelle für theoretische und praktische Informationen, mit denen sich die Rolle der Psychologie im Zusammenhang mit Sport, Bewegung und Leistung besser verstehen lässt und die zeigen, wie dieses Verständnis für die Ergebnisverbesserung in der Praxis Anwendung findet. Die 4. Auflage des Handbook of Sports Psychology präsentiert in acht Abschnitten neue Informationen zu neuen Gebieten, wie Achtsamkeit, Hirnkartierung, Selbstbewusstsein, mentale Stärke, und behandelt Spezialthemen wie Geschlecht, kulturelle Diversität, Sportler mit Behinderungen, Alkohol und Drogen im Sport. Darüber hinaus werden klassische Themen erörtert, z. B. Motivationsauslöser für sportliche Leistungen, Druck als Ansporn, Topathleten und ihr Umgang mit Führungsrollen, Bedeutung von mentalem Training, Umgang mit Verletzungen u.v.m. - 4. Auflage diese einflussreichen Referenzwerks der Sportpsychologie. - Neue Inhalte, u. a. Achtsamkeit in der Sport- und Bewegungspsychologie, Ethik, mentale Stärke, Sportsozialisierung, Einsatz von Brain-Technologien in der Praxis. - Unterstützt von der International Society of Sport Psychology (ISSP). Die 4. Auflage des Handbook of Sports Psychology ist ein Muss für Studenten und Praktiker, die sich für Sportpsychologie interessieren.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. The two volumes on “Phosphoinositides” provide a concise overview of the latest developments in the field of phosphoinositide hemostasis and function, and provide introductory background and extensions into unexplored territory.