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Oncology has developed as a subspecialty of medicine with unique and often complex clinical problems. This handbook ofhematologic and oncologic emer gencies provides a compact, concise, yet comprehensive guide to the manage ment of a variety of difficult clinical situations. The authors of the various chapters are all clinicians with experience in the management of these difficult patients. Their efforts provide insight and a ready source of practical infor mation which lends itself to use in the clinic and in the inpatient ward. The authors sincerely hope that this handbook will be of service to house officers and fellows alike, as they develop skills in the management of the emergent problems of patients with hematologic and other neoplasms. Janice P. Dutcher Peter H. Wiernik Bronx, New York, ;; Contents 1. Syndrome of Inappropriate Antidiuretic Hormone Secretion and Hyponatremia ... 000 ... Stuart L. Marcus, M.D., Ph. D., and Joachim Z. Fuks, M.D. 1. Introduction ... 1 2. Mechanisms ... 3 3. Etiology ... . 3 4. Diagnosis ... 5 5. Treatment ... . 6 References ... . 8 2. Acute Tumor Lysis Syndrome: Prevention and Management . . 9 Stuart L. Marcus, M.D., Ph. D., and Avi I. Einz;ig, M.D. 1. Introduction ... 9 2. Risk Factors for the Development of Azotemia in Acute Tumor Lysis Syndrome ... 10 3. Metabolic Abnormalities That Occur during Acute Tumor Lysis Syndrome ... 11 ... 4. Prevention of Acute Tumor Lysis Syndrome: Management prior to Beginning Chemotherapy ... 13 ... 5. Posttreatment Management: Indications for Dialysis ... 14 . . References ... 15 ...
This new resource on managing oncologic emergencies is directed at all health care professionals who care for patients with cancer or survivors. Edited and written by clinician-experts at The University of Texas MD Anderson Cancer Center, the book covers the full range of oncologic emergencies, from cardiac and neurologic to orthopedic to hematologic, and addresses important palliative care, ethical, and Emergency Department considerations. Chapters are structured with busy clinicians in emergent and urgent settings in mind, and each chapter concludes with a series of key practice points and a list of suggested readings for those who wish to delve deeper into a subject. For any clinician facing the increasing number of patients who experience an oncologic emergency, this is an up-to-date, clinically focused, and authoritative resource.
An innovative new survival guide for the pediatric intensive care unit (PICU) The PICU Handbook is a unique, pocket-sized compilation of the data necessary for residents and fellows to navigate the modern Level 1 and Level 2 pediatric intensive care unit. Enhanced by numerous tables, formulas, algorithms, guidelines, checklists, rapid-sequence medication formularies, troubleshooting guides, and clinical pearls, this is a true must read for all junior clinicians and pediatric critical care nurses. Readers will find wide-ranging coverage of every critical issue they will encounter in the PICU, including airway clearance, respiratory mechanics and respiratory failure, endotracheal intubation, shock, brain death evaluation, and much more. The PICU Handbook is edited by the Associate Medical Director of Children’s Memorial Hospital/Ann & Robert H. Lurie Children’s Hospital of Chicago, and features contributions from current and former pediatric residents and pediatric critical care fellows.
Lanzkowsky's Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks. - Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures - New chapter on Pediatric Vascular Anomalies - New content on 'blood avoidance' programs to honor religious preferences - Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders - Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases
This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.
Designed specifically for nephrologists and trainees practicing in the ICU, Handbook of Critical Care Nephrology is a portable critical care reference with a unique and practical nephrology focus. Full-color illustrations, numerous algorithms, and intuitively arranged contents make this manual a must-have resource for nephrology in today’s ICU.
The Essential Therapy Guide to Cancer, Hematologic Disorders, and Supportive Care--Updated with the Latest Treatment Regimens More than 500 treatment regimens A Doody’s Core Title for 2019! Hematology-Oncology Therapy, Second Edition is an up-to-date, comprehensive therapy guide that delivers more than 500 treatment regimens in a succinct, uniformmanner. The unique tabular design allows you to instantly locate and implement the proper treatment regimen. Supported by the latest practice guidelines, peer-reviewed literature, and the opinion of experts, Hematology-Oncology Therapy integrates extensive informationthat is critical to both office- and hospital-based practice of hematology and oncology. Hematology-Oncology Therapy is divided into three sections: Oncology: Provides detailed information about the administration, supportive care, toxicity, dose modification, monitoring, and efficacy of commonly used and recently approvedchemotherapeutic regimens, drugs, and biological agents Supportive Care, Drug Preparation, Complications, and Screening: Consists of topics commonly encountered in clinical hematology-oncology practice, such as chemotherapy-induced nausea, oncologic emergencies, radiation complications, cancer pain management, cancer screening, and much more Selected Hematologic Diseases: Delivers an authoritative guide to therapy for the principal diseases in consultative hematology This edition of Hematology-Oncology Therapy is enriched by the updating of all chapters as well as the addition of several new chapters; the new "Expert Opinion," which provides recommendations and guidance from experts on the use of treatment regimens; and inclusion of the latest regimens.
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition, provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. This edition offers state-of-the-art content, including coverage of new anti-cancer drugs and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for internists and other primary care providers.