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Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden. This book, volume 4 of the Advances in Alzheimer’s Disease book series which is published in coordination with the Journal of Alzheimer’s Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment. Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.
Presents cutting-edge information on a variety of dementia-causing illnesses. Provides relevant material for professionals working with AIDS patients, substance abusers, stroke or other vascular patients, and other individuals suffering from degenerative illness. Edited by leading experts in geriatric health and dementia.
The Handbook of Mental Health and Aging, Third Edition provides a foundational background for practitioners and researchers to understand mental health care in older adults as presented by leading experts in the field. Wherever possible, chapters integrate research into clinical practice. The book opens with conceptual factors, such as the epidemiology of mental health disorders in aging and cultural factors that impact mental health. The book transitions into neurobiological-based topics such as biomarkers, age-related structural changes in the brain, and current models of accelerated aging in mental health. Clinical topics include dementia, neuropsychology, psychotherapy, psychopharmacology, mood disorders, anxiety, schizophrenia, sleep disorders, and substance abuse. The book closes with current and future trends in geriatric mental health, including the brain functional connectome, repetitive transcranial magnetic stimulation (rTMS), technology-based interventions, and treatment innovations. Identifies factors influencing mental health in older adults Includes biological, sociological, and psychological factors Reviews epidemiology of different mental health disorders Supplies separate chapters on grief, schizophrenia, mood, anxiety, and sleep disorders Discusses biomarkers and genetics of mental health and aging Provides assessment and treatment approaches
Not only is depression among the elderly treatable but, given its increase in incidence and a rapidly aging population, it is a critical issue for the mental-health and medical communities. The authors review the range of late-life depressive syndromes and the strategies for assessing and treating them, and illustrate the problems and principles with fourteen extended case studies-rare in the geropsychology literature and the core of the book. They also provide a guide to medications, screening tools, innovative models, and supplementary resources, invaluable tools for mental-health professionals and medical practitioners alike.
From New York Times bestselling author and expert on neuroscience, memory, Alzheimer’s Disease, dementia, anxiety and human behavior, The Small Guide to Depression provides a comprehensive overview of depression, negative personality traits and anxiety -- along with the latest treatment solutions from conventional and alternative therapies to new scientific discoveries and interventions. Over 300 million people worldwide live with depression; in 2014, around 15.7 million adults age 18 or older in the U.S. had experienced at least one major depressive episode in the last year. This accessible guide starts with providing readers with an overview of depression: What it is, who gets it, how to recognize it, major causes (genetics, environment, etc.). Dr. Small discusses the various types of depression General therapeutic approaches used for all depression disorders How to know when it’s time to seek professional help. Each of the chapters will cover a specific type of depression and open with a case study example. Small will describe: Causes, symptoms, conventional treatments (e.g., medications, psychotherapy) Alternative therapies (e.g., exercise, meditation, yoga, homeopathy) Novel therapies (e.g., transmagnetic stimulation [TMS]) New scientific discoveries and interventions coming down the pike (e.g., focused ultrasound). In addition to case studies and patient interviews, all chapters will include side-bars with factoids, lists, and other helpful information.
A reference on preventing, treating, and coping with dementia, from “one of the most reliable, respected health resources that Americans have” (Publishers Weekly). This book from the world-renowned Mayo Clinic offers an update on what experts know about Alzheimer’s and related dementias, including the latest research into treatment and prevention, ways to live well with dementia, and recommendations for caregivers. While Alzheimer’s disease is the most common type of dementia, many related types also affect adults worldwide, causing loss of memory, reason, judgment, and other cognitive functions. Although the diseases that cause dementia have long been considered unrelenting and incurable, recent advances offer hope. This book includes information about: • What to expect of typical aging and what are the earliest signs of abnormal aging • Memory loss and other forms of cognitive impairment that may lead to dementia • Characteristic features of Alzheimer’s disease and related dementias, including frontotemporal degeneration, Lewy body dementia, and vascular cognitive impairment • The latest research on Alzheimer’s disease and related dementias • Caring for and supporting someone living with dementia Are there ways you can lower your risk? Can dementia be prevented? Can you live well with dementia? If so, how? You’ll find answers to these important questions and more in this book.
This comprehensive update offers practical advice for professionals working in neuropsychology with older adults. Focusing on fundamentals, common issues, special considerations, and late-life cognitive disorders, respected names in this critical specialty address a wide range of presenting problems and assessment, diagnostic, and treatment concerns. Th roughout, coverage pays keen attention to detail, bringing real-world nuance to large-scale concepts and breaking down complex processes into digestible steps. And like its predecessor, the new Handbook features recommendations for test batteries and ends each chapter by extracting its “clinical pearls.” A sampling of the topics covered: • Assessment of depression and anxiety in older adults. • The assessment of change: serial assessments in dementia evaluations. • Elder abuse identifi cation in older adults. • Clinical assessment of postoperative cognitive decline. • Cognitive training and rehabilitation in aging and dementia. • Diff erentiating mild cognitive impairment and cognitive changes of normal aging. • Evaluating cognition in patients with chronic obstructive pulmonary disease. This Second Edition of the Handbook on the Neuropsychology of Aging and Dementia offers a wealth of expert knowledge and hands-on guidance for neuropsychologists, gerontologists, social workers, and other clinicians interested in aging. Th is can be a valuable reference for those studying for board certifi cation in neuropsychology as well as a resource for veteran practitioners brushing up on key concepts in neuropsychology of age related disorders.
First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer’s Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.