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Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.
CD-ROM includes animations, living graphs, biochemistry in 3D structure tutorials.
Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
People go traveling for two reasons: because they are searching for something, or they are running from something. Katie’s world is shattered by the news that her headstrong and bohemian younger sister, Mia, has been found dead at the bottom of a cliff in Bali. The authorities say that Mia jumped—that her death was a suicide. Although they’d hardly spoken to each other since Mia suddenly left on an around-the-world trip six months earlier, Katie refuses to accept that her sister would have taken her own life. Distraught that they never made peace, Katie leaves her orderly, sheltered life in London behind and embarks on a journey to find out the truth. With only the entries in Mia’s travel journal as her guide, Katie retraces the last few months of her sister’s life and—page by page, country by country—begins to uncover the mystery surrounding her death. . . . Weaving together the exotic settings and suspenseful twists of Alex Garland’sThe Beachwith a powerful tale of familial love in the spirit of Rosamund Lupton’sSister, Swimming at Nightis a fast-paced, accomplished, and gripping debut novel of secrets, loss, and forgiveness.
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
"[The book] has been designed for one- and two-semester courses for undergraduates majoring in biochemistry and related disciplines, as well as for graduate students who require a broad introduction to biochemistry. It is also suited for courses at medical, dental, veterinary, pharmacy, and other professional schools. The book will be used most successfully by students who have completed two years of college-level chemistry, including organic chemistry, and have received at least an introduction to biology. While some background in physics and physical chemistry would be useful, all relevant principles are introduced in a manner that should make them accessible to most students"--Preface.
In The Logic of Life François Jacob looks at the way our understanding of biology has changed since the sixteenth century. He describes four fundamental turning points in the perception of the structure of living things: the discoveries of the functions of organs, cells, chromosomes and genes, and DNA.