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Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.
This guidance manual presents the potential benefits and costs associated with Extended Producer Responsibility.
This manual suggests design operating and performance criteria for specific surface water quality conditions to provide the optimum protection from microbiological contaminants.
A Buddhist Classic A practical manual for both teacher and student alike, Clarifying the Natural State covers the path from mindfulness to complete enlightenment, simply and methodically. Presenting the profound and ultimate instructions of Mahamudra, it embodies the realization of India and Tibet's greatest masters. The words of Dakpo Tashi Namgyal are unique. Adorned with plenty of pithy advice out of his personal experience, practitioners are greatly benefited by his instructions on how to remove hindrances and progress further. His methods for practicing Mahamudra are preeminent. This book is indispensable as it focuses exclusively on practice. -Khenchen Thrangu Rinpoche Elevate your experience and remain wide open like the sky. Expand your mindfulness and remain pervasive like the earth. Steady your attention and remain unshakable like a mountain. Brighten your awareness and remain shining like a flame. Clear your thought free wakefulness and remain lucid like a crystal. - Dakpo Tashi Namgyal 16th Century