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This comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.
The processes and mechanisms that control the growth of woody plants are of crucial importance for both economic and biological reasons. The comprehensive coverage of Growth Control in Woody Plants includes discussion of the growth controlling factors in both reproductive structures (flowers, fruit, seeds, pollen, etc.) and vegetative organs (stems, branches, leaves, and roots). Other major topics covered include seed germination, seedling growth, physiological and environmental regulation of growth, cultural practices, and biotechnology.This comprehensive treatment of the many factors that control the growth of woody plants can serve both as a valuable text and as a frequently used reference.* Includes comprehensive representation of a broad subject* Provides thorough bibliographic coverage * Well illustrated* Serves as a vital companion to Physiology of Woody Plants, Second Edition
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.
Advocates of growth management and smart growth often propose policies that raise housing prices, thereby making housing less affordable to many households trying to buy or rent homes. Such policies include urban growth boundaries, zoning restrictions on multi-family housing, utility district lines, building permit caps, and even construction moratoria. Does this mean there is an inherent conflict between growth management and smart growth on the one hand, and creating more affordable housing on the other? Or can growth management and smart growth promote policies that help increase the supply of affordable housing? These issues are critical to the future of affordable housing because so many local communities are adopting various forms of growth management or smart growth in response to growth-related problems. Those problems include rising traffic congestion, the absorption of open space by new subdivisions, and higher taxes to pay for new infrastructures. This book explores the relationship between growth management and smart growth and affordable housing in depth. It draws from material presented at a symposium on these subjects held at the Brookings Institution in May 2003, sponsored by the U.S. Department of Housing and Urban Development, the National Association of Realtors, and the Fannie Mae Foundation. Contributors seek to inform the debate and provide some useful answers to help the nation accommodate the curtailment of growth in urban and suburban domains while still ensuring a supply of affordable housing. Contributors include Karen Destorel Brown (Brookings), Robert Burchell, (Rutgers University), Daniel Carlson (University of Washington), David L. Crawford (Econsult Corporation), Anthony Downs (Brookings), Ingrid Gould Ellen (New York University), William Fischel (Dartmouth College), George C. Galster (Wayne State University), Jill Khadduri (Abt Associates), Gerrit J. Knaap (University of Maryland), Robert Lang (Virginia Polytechnic
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
The purpose of this book is to provide information on senescent cells and why they are prevented from multiplying via cell division. It includes main sections on the nature of Go/1 transition, factors promoting the cell cycle traverse and avoiding the Go/1 arrest, and negative factors arresting the cell cycle traverse and promoting the stay in the Go/1 stage. Filled with illustrations and explanations, it collectively presents the mechanisms that control the cellular aging process. This reference is a must for anyone with special interests in the biological community, and specifically the field of gerontology.
In this thoroughly revised edition of Managing Growth in America’s Communities, readers will learn the principles that guide intelligent planning for communities of any size, grasp the major issues in successfully managing growth, and discover what has actually worked in practice (and where and why). This clearly written book details how American communities have grappled with the challenges of planning for growth and the ways in which they are adapting new ideas about urban design, green building, and conservation. It describes the policies and programs they have implemented, and includes examples from towns and cities throughout the U.S. Growth management is essential today, as communities seek to control the location, impact, character, and timing of development in order to balance environmental and economic needs and concerns. The author, who is one of the nation’s leading authorities on managing community growth, provides examples from dozens of communities across the country, as well as state and regional approaches. Brief profiles present overviews of specific problems addressed, techniques utilized, results achieved, and contact information for further research. Informative sidebars offer additional perspectives from experts in growth management, including Robert Lang, Arthur C. Nelson, Erik Meyers, and others. In particular, he considers issues of population growth, eminent domain, and the importance of design, especially green design. He also reports on the latest ideas in sustainable development, smart growth, neighborhood design, transit-oriented development, and green infrastructure planning. Like its predecessor, the second edition of Managing Growth in America’s Communities is essential reading for anyone who is interested in how communities can grow intelligently.
This book summarizes how 443 of California's cities and counties dealt with problems caused by rapid growth in the 1970s and 1980s. Maps, charts, and graphs illustrate the distribution of different types of growth control measures throughout the state. This report is a valuable resource in light of changing social and economic conditions in the late 1990s and early 2000s.
It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.