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The framework aims to provide global perspectives on principles, tools and mechanisms to support Member States and relevant stakeholders to mitigate and prevent biorisks and govern dual-use research. The framework adopts the One health approach and focuses on the role that responsible life sciences research can play in preventing and mitigating risks caused by accidents, inadvertent or deliberate misuse with the intention to cause harm to humans, nonhuman animals, plants and agriculture, and the environment. The framework is primarily intended for those who have responsibilities in the governance of biorisks, such as policy makers and regulators in charge of developing national policies to harness the potential benefits of the life sciences while constraining their risks. The framework is also directed towards scientists and research institutions, educators, trainers, project management staff, funding bodies, publishers, editors, the private sector and all relevant stakeholders that are part of the research life cycle. The governance of biorisks is an issue that should engage all countries, although countries will have different contexts, needs and starting points. Mitigating these risks will require individual and collective actions among different stakeholders and disciplines. Mitigating biorisks and governing dual-use research is a shared responsibility.
This report summarizes the discussions of a two-day technical workshop on the operationalization of the global guidance framework in the WHO African Region and the discussions of the partners’ meeting, held in Nairobi, Kenya, on 24-25 January 2023. The workshop, which was organized by the WHO Science Division, in collaboration with the WHO Regional Office for Africa and the Africa Centres for Disease Control and Prevention (Africa CDC), was aimed at discussing the framework and other related existing regional initiatives; facilitating the sharing of knowledge and experience of countries on the challenges and needs in mitigating biorisks and governing dual-use research; strengthening collaboration among multiple and multidisciplinary stakeholders within the WHO African Region; identifying the needs for additional toolkits or regional guidance; and recommending concrete actions for the roll-out of a national implementation of the framework.
The WHO Science Division organized a Consultative Meeting on a Global Guidance Framework to Harness the Responsible Use of the Life Sciences, on 11 March 2021, bringing a broad range of stakeholders that included academia, scientists and researchers, publishers and editors, security actors, public health officers, policy makers, research donors, and representatives from regional and UN entities. The objectives of the meeting were to consult on the scope of the Global Guidance Framework and on the critical elements this framework should address. The outcomes of this consultation will contribute to inform the development of the Global Guidance Framework. The meeting consisted of presentations and plenary discussions guided by a series of key questions. Overall, participants recommended to set up, at international level, a common terminology covering safe, secure and responsible research. Two major themes emerged during the discussions: the need for an overall risk management and a unified approach as well as the importance of awareness, education and training across the different stakeholder groups.
The Technical Advisory Group on the Responsible Use of the Life Sciences and Dual-Use Research (TAG-RULS DUR) was established in November 2023 to provide independent advice to WHO including on technical and strategic advice relevant to the monitoring and mitigation of biorisks, advances in the life sciences and related technologies, the governance of dual-use research and the responsible use of the life sciences. On 24 January 2024, eighteen members of the TAG-RULS DUR virtually met to introduce TAG-RULS DUR members; to discuss current and future activities related to the responsible use of the life sciences and dual-use research; and to share the members’ perspectives and visions on the work ahead.
This book explores how revolutionary developments and convergence of the chemical, life and associated sciences are impacting contemporary toxin and bioregulator research, and examines the risks of such research being misused for malign purposes. Investigating illustrative cases of dual use research of potential concern in China, India, Iran, Russia, Syria and the USA, the authors discuss how states can ensure such research and related activities are not utilised in weapons development. Although toxins and bioregulators are, in theory, covered by both the Biological and Toxin Weapons Convention and Chemical Weapons Convention, this apparent overlap in reality masks a dangerous regulatory gap – with neither Convention implemented effectively to address threats of weaponisation. This book highlights the potentially damaging consequences for international peace and security, and proposes realistic routes for action by states and the scientific community.
This innovative and comprehensive collection of essays explores the biggest threats facing humanity in the 21st century; threats that cannot be contained or controlled and that have the potential to bring about human extinction and civilization collapse. Bringing together experts from many disciplines, it provides an accessible survey of what we know about these threats, how we can understand them better, and most importantly what can be done to manage them effectively. These essays pair insights from decades of research and activism around global risk with the latest academic findings from the emerging field of Existential Risk Studies. Voicing the work of world leading experts and tackling a variety of vital issues, they weigh up the demands of natural systems with political pressures and technological advances to build an empowering vision of how we can safeguard humanity’s long-term future. The book covers both a comprehensive survey of how to study and manage global risks with in-depth discussion of core risk drivers: including environmental breakdown, novel technologies, global scale natural disasters, and nuclear threats. The Era of Global Risk offers a thorough analysis of the most serious dangers to humanity. Inspiring, accessible, and essential reading for both students of global risk and those committed to its mitigation, this book poses one critical question: how can we make sense of this era of global risk and move beyond it to an era of global safety?
This book reflects on work done through the Managing Extreme Technological Risk (METR) project, a pioneering research programme within the Centre for the Study of Existential Risk, University of Cambridge. METR has been both an exercise in 'academic engineering' to address major global challenges, and a research programme that extends beyond traditional academic outputs into methodological development and innovative forms of expert engagement and outreach.Managing Extreme Technological Risk explores how the METR programme developed a model that is needed to effectively understand risks to the survival of humanity, as well as their management and mitigation. It reflects on the challenges faced and lessons learned in the process of building a research community focused on this aim. This book brings together findings and future considerations from a key formative phase, not just for the Centre, but for the field of existential risk and aligned areas of research as a whole. It relates the story of this journey and outlines some of the programme's specific findings. There is an overall focus on what has been learnt for approaching the study of existential risk and how this can, and must, be taken forward by others, urgently and at scale.
Essentials of Biological Security A guide to minimizing the threat of misusing benignly intended and dual-use biological research In Essentials of Biological Security: A Global Perspective, a team of distinguished researchers delivers a fundamental resource designed to raise awareness and understanding of biological security as it pertains to the malign manipulation of benignly intended scientific research. Written by experts who have spent decades involved in biological security issues, the book is systematically organized to make it accessible to a wide range of life scientists likely to encounter dangerous opportunities for the deliberate misuse of their research. Readers will also find: A thorough introduction to biological security and the chemical and biological weapons (CBW) threat spectrum Comprehensive explorations of the history of biological weapons from antiquity to modern day Practical discussions of dual-use technologies and how to minimize their risk Expert analyses of the Biological and Toxin Weapons Convention and other relevant international agreements and organizations Perfect for professionals working in life sciences, medicine, global health, biosafety, and biosecurity, Essentials of Biological Security: A Global Perspective will also benefit anyone with an interest in and being responsible for biological security.