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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GVHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GVHD prevention and treatment.
This book presents international experimental and clinical experience on limb transplantation and other composite tissue allografts, representing the most complete and comprehensive review of this innovative and ground breaking procedure. This book is a milestone in medical literature and an asset for every scientific library.
Animal cell technology has been making tremendous progress. Originally this term reminded people of engineering for high density and large volume culture of animal cells. At present many fields of biological sciences are aiming at advance in animal cell technology. Cell culture engineering is aided not only with developments in apparatus, matrix, media, and computational analysis, but also with new biological procedures in gene and protein technology, cell biological resources and immunological methods. Results obtained with animal cell technology are applied to production of pharmaceuticals, diagnosis reagents and food endowed with physiological functions, and cell and gene therapy of animals and humans, and useful for elucidating scientific phenomena. It is also essential to establish methods of evaluation for functionality and safety of newly discovered molecules and cells. The progress in animal cell technology is supported by, and attributes in both of basic and applied sciences. The proceedings of the Fifth International Meeting of the Japanese Association for Animal Cell Technology (JAACT) covers the subjects above mentioned. The articles in this book will help researchers in many fields to understand the current status and future trends in animal cell technology. JAACT organized this Meeting and we express our gratitude to the members of JAACT. We gratefully acknowledge all the members of the organizing committee for their dedication in assuring the Meeting's success. For their valuable supports, we also thank the Japanese Biolndustry Association and Saitama Foundation for Culture and Industry.
This comprehensive work provides a description of specific autoimmune diseases, the known ethiopathic immune mechanisms, and the effects of all immunosuppressive drugs in regular use. The unified format and up-to-date references uniquly suit this work to be a text for advanced medical classes as well a review for practicing clinicians.