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"The COVID-19 disaster in California's prisons stands out as the worst medical prison catastrophe in the state's history. Three-quarters of the state's prison population was infected; 264 incarcerated people and 50 staff members died. In Fester, authors Hadar Aviram and Chad Goerzen expose the COVID-19 correctional experience through hundreds of first-person accounts, months of courtroom observations, years of carefully collected quantitative COVID-19 data, and a wealth of policy documents. Already vulnerable from decades of overcrowding and abysmal healthcare, California's prison population bore the brunt of the COVID-19 horror. Fester bears witness to the immense suffering we bring on ourselves and our fellow humans through dehumanization, fear, and ignorance, and stands as a monument for a brave coalition of incarcerated and formerly incarcerated people, family members and loved ones, advocates and activists, doctors and journalists, who worked to shed light on one of the darkest times in the Golden State's correctional system"--
I always knew that the rest of my story is gonna be a good one. I don’t know how I knew that, but I always did. Ungow! I am Fester the cat. Welcome to my book, everyone! From when he first ambled into Paul Magrs’s yard—skinny, covered in flea bites, and missing all but one and a half teeth—Fester knew he’d found his family. Paul and his partner, Jeremy, thought it was the ragged black-and-white stray, tired from a rough life on the streets, who was in desperate need of support. But clever Fester knew better. He understood that it was his newfound owners who needed the help. Over the course of seven years, the feisty feline turned the quaint Manchester house into a loving home. Through his fierce spirit, strong will, and calming energy, Fester taught Paul and Jeremy how to listen and breathe, how to appreciate the joys of simply sitting and singing (what Fester’s purrs sounded like to his silly humans), and how to find joy and contentment in life, even when dealing with hardship. This is the true story of an extraordinary little cat whose gentle charm and trusting soul turned two young men into a family.
The twentieth century promised much in terms of progress. Europe was at peace, and America was poised to become a world superpower. Certain religious leaders envisioned new programs to help the poor, while others pondered plans to evangelize the world. Protestants in America were divided over issues such as biblical authority and social programs, but there was a surface unity, and a widespread agreement (shared with Catholic and Orthodox Christians) about the sanctity of human life, an ethic rooted in the Bible and church history. Seventy nations, responding to medical advances in obstetrics, fetology, and a growing concern for women’s health, had moved to prohibit abortion. Today, 120 years later, there is a deep division among Christians, and in American society, about abortion (and much else). The causes are no doubt complex, but several things are clear. Worldwide there have been over one billion unborn children destroyed by abortion. There have been seventy-three million unborn children destroyed by abortion in the United States, over half of them to women who identify as Christians. In a century of massive violence due to war, planned famines, mass executions, and terror, abortion reigns supreme. That the Judeo-Christian ethic of the sanctity of life has been shredded owes much to the scandal of Christian discipleship.
When Flower Shop owner Bretta Solomon leaves her hometown of River City, Missouri, and heads for a florist convention in Branson, she's surprised to find a letter from Vincent and Mabel McDuffy slipped under her hotel room door, begging for help. The McDuffys seem to know of Bretta's success as an amateur sleuth around River City, and that, coupled with their admiration for Bretta's late husband, a police officer, has inspired them to ask Bretta to find out what happened to their daughter, who died of a heart attack a few months ago. The trouble is, Bretta can't find the McDuffys-after leaving her several messages at the hotel, they seem to have vanished. And although she's curious to track them down and find out exactly what they want her to do, she's got her hands full already running the design contest at the annual florist convention, coping with back-stabbing competitors and suspicious colleagues. Once again, Janis Harrison's likable and enterprising sleuth, Bretta Solomon, unearths a murderer in the unlikeliest of places. Combining a traditional puzzle with a delightful gardening backdrop, this charming mystery distinguishes a series that continues to bloom.
transmembrane helices and a short intracellular tail. Sequences from over 70 individuals collected from populations along the West Coast of North America and two populations from the North East coast revealed that uncle fester is remarkably non-polymorphic, with only two single nucleotide polymorphisms and one amino acid deletion found to be segregating within these populations. I first determined uncle fester expression by RT-PCR, and found that expression begins in the early stages of embryonic development, and continues throughout the life cycle of the individual. These studies also revealed that uncle fester is alternatively spliced in the embryo, tadpole and adult stages of development. Each adult examined thus far expresses three alternative splice variants; however, embryos and tadpole larvae express an additional set of splice variants. The roles of these splice variants remain unknown. I then performed in situ hybridization on tadpole larvae, juveniles and adult colonies using an uncle fester specific riboprobe, to determine where the uncle fester mRNA is localized. The results indicate that uncle fester mRNA is found on the larval adhesive papillae, the epithelia of the ampullae and on a subset of blood cells, all tissues known to be involved in the allorecognition response. I also created two monoclonal antibodies to the uncle fester protein, and results from whole-mount immunohistochemistry are concordant with the mRNA in situ hybridization data. The methods and characterization of the uncle fester antibodies can be found in Chapter 4. Previous studies have shown that fester is also expressed along the epithelia of the ampullae. To determine if both proteins are co-expressed on the same populations of cells, I performed double-labeled FACS and IF using directly conjugated fester and uncle fester mAbs. Results indicated that all cells that express uncle fester also express fester, and in addition there is a population of fester+/uncle fester- cells found migrating within the tunic. To determine if uncle fester was functionally involved in the allorecognition response, I used two distinct approaches. First, I delivered custom siRNA to individuals while surgically removing the ampullar tissue, essentially forcing the animals to regenerate new ampullae under the effects of the siRNA and eliminating the uncle fester protein. When incompatible colonies were paired while under the effects of siRNA, the allorecognition response was never initiated and the two colonies eventually grew over the top of each other. However, the application of uncle fester siRNA had no effect on compatible colonies, suggesting that the activation of a rejection reaction is independent of a fusion response. The second approach was to stimulate function using the uncle fester specific monoclonal antibodies. By conjugating the mAb to magnetic beads, I was able to localize the antibody to the epithelia of ampullae, which resulted in the formation of strong points of rejection on a single colony. In summary, I found that uncle fester is a non-polymorphic type I transmembrane protein that expresses a limited repertoire of alternative splice variants. It is co-localized with both the fuhc and fester on all tissues important to the allorecognition response. Functionally, uncle fester is required to activate a rejection response, but plays no role in compatible interactions. These results have transformed our working hypothesis from allorecognition consisting of a single activating pathway, to one consisting of two independent activating and inhibitory pathways that control histocompatibility outcomes.
Crime Doesn't Pay! Two pea-sized detectives need to find the criminals who robbed the Bank of Dozer and kidnapped the bank owner's grandson before the trail goes cold.
Welcome to Fester, Pennsylvania. Population: weird. Chief Constable Billy Snyder keeps the town in line, enforcing the law with an iron fist while he runs his own lucrative scams on the side. He serves as guard dog for the elite Top Hats, descendants of Fester's original settlers, who for centuries have been keeping a dark secret in the Wizard's Woods south of town. When circumstances threaten to reveal the Top Hats' secret, Snyder puts his best man on the case: Inspector Martin Prieboy. The Batman-obsessed inspector-one of Fester's few honest cops-soon finds himself in over his head. Now he has to contend with two big cases: a murder/suicide at the local college and the mysterious disappearance of a well-respected nurse. Further complicating matters are the machinations of a drug-pushing rodeo clown, a group of cataclysmically inept Satanists, a family of crazed hillbillies, and an old-school Germanic witchdoctor. And that new drug that's going around town-is it just bad medicine or a genuine gateway to the spirit realm? Against all of these odds and oddities, Snyder and Martin struggle to keep a lid on the town's troublemakers. When two love-struck teens make a fearsome discovery in the Wizard's Woods, the volatile mixture of mystery and greed begins to burn, threatening the Top Hats' secret and the future of Fester!