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This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.
Many areas of knowledge converge in the building industry and therefore research in this field necessarily involves an interdisciplinary approach. Effective research requires strong relation between a broad variety of scientific and technological domains and more conventional construction or craft processes, while also considering advanced management processes, where all the main actors permanently interact. This publication takes an interdisciplinary approach grouping various studies on the building industry chosen from among the works presented for the 2nd International Conference on Construction and Building Research. The papers examine aspects of materials and building systems; construction technology; energy and sustainability; construction management; heritage, refurbishment and conservation. The information contained within these pages may be of interest to researchers and practitioners in construction and building activities from the academic sphere, as well as public and private sectors.
The available material in English discussing Latin American anarchism tends to be fragmentary, country-specific, or focused on single individuals. This new translation of Ángel Cappelletti's wide-ranging, country-by-country historical overview of anarchism's social and political achievements in fourteen Latin American nations is the first book-length regional history ever published in English. With a foreword by the translator. Ángel J. Cappelletti (1927–1995) was an Argentinian philosopher who taught at Simon Bolivar University in Venezuela. He is the author of over forty works primarily investigating philosophy and anarchism. Gabriel Palmer-Fernandez is Distinguished Professor of Philosophy and Religious Studies at Youngstown State University.
Spanish Marxism Versus Soviet Communism is the first historical study of the P.O.U.M. to appear in English. Drawing from his multi-volume work on the subject, which was published in Spanish and Catalan, Victor Alba has collaborated with Stephen Schwartz to produce a condensed and amplified study that is far more than a translation. Outside Spain, the political movement known as the Workers Party of Marxist Unification (Partido Obrero de Unificacion Marxist or P.O.U.M.) is chiefly known as the revolutionary group with which George Orwell fought during the Spanish Civil War of the 1930s. The events in which the P.O.U.M. found itself at the center of conflict between Iberian revolutionaries and Soviet interests remain a controversial topic for historians and other writers. This book presents a detailed picture of the organization and its main antecedent, the Workers' and Peasants' Bloc, in the context of a stimulating working class political culture. Those interested in Catalan history as well as historians of Western European Marxism and the Spanish Civil War will find this book useful. It will also be of interest to those concerned with Orwell and his experience in Spain. A fitting tribute to the P.O.U.M.'s great struggle against Stalinism, Spanish Marxism Versus Soviet Communism will surely stand out among the array of books that have been published on the Spanish Civil War period as a definitive study.
“This collection, because of its exceptional theoretical coherence and sophistication, is qualitatively superior to the most frequently consulted anthologies on Latin American women’s history and literature . . . [and] represents a new, more theoretically rigorous stage in the feminist debate on Latin American women.”—Elizabeth Garrels, Massachusetts Institute of Technology
Unlike a conventional war waged against a standing army, a "dirty war" is waged against individuals, groups, or ideas considered subversive. Originally associated with Argentina's military regime from 1976-1983, the term has since been applied to neighboring dictatorships during the period. Indeed, it has become a byword for state-sponsored repression anywhere in the world. The first edition of this reference illustrated the concept by describing the regimes of Argentina, Chile (1973-1990), and Uruguay (1973-1985), which tortured, murdered, and disappeared thousands of people in the name of anticommunism while thousands more were driven into exile. The second edition expands the scope to include Bolivia (1971-1982), Brazil (1964-1985), and Paraguay (1954-1989). Includes a chronology, an introductory essay, a bibliography, and over 400 cross-referenced dictionary entries on the countries; guerrilla and political movements; prominent guerrilla, human-rights, military, and political figures; local, regional, and international human-rights organizations; and artistic figures (filmmakers, novelists, and playwrights) whose works attempt to represent or resist the period of repression.--Publisher.
Brock's thorough investigation of the evidence in the Thomas-Hill hearings concluded that there was no reason to believe Anita Hill's accusations of sexual harassment against Clarence Thomas. Brock's book--a national sensation which landed on the New York Times bestseller list--is the definitive rebuttal of Hill's charges.
At the beginning of the twentieth century, Venezuela had one of the poorest economies in Latin America, but by 1970 it had become the richest country in the region and one of the twenty richest countries in the world, ahead of countries such as Greece, Israel, and Spain. Between 1978 and 2001, however, Venezuela’s economy went sharply in reverse, with non-oil GDP declining by almost 19 percent and oil GDP by an astonishing 65 percent. What accounts for this drastic turnabout? The editors of Venezuela Before Chávez, who each played a policymaking role in the country’s economy during the past two decades, have brought together a group of economists and political scientists to examine systematically the impact of a wide range of factors affecting the economy’s collapse, from the cost of labor regulation and the development of financial markets to the weakening of democratic governance and the politics of decisions about industrial policy. Aside from the editors, the contributors are Omar Bello, Adriana Bermúdez, Matías Braun, Javier Corrales, Jonathan Di John, Rafael Di Tella, Javier Donna, Samuel Freije, Dan Levy, Robert MacCulloch, Osmel Manzano, Francisco Monaldi, María Antonia Moreno, Daniel Ortega, Michael Penfold, José Pineda, Lant Pritchett, Cameron A. Shelton, and Dean Yang.