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Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen
In a sleepy resort town, Maud Chadwick waits tables at the Rainbow Cafe. Her confidant is Sheriff Sam DeGheyn and what they have in common is obsession. Maude doesn't want her son to leave home, and Sam cannot let go of the unsolved murders of three local women -- or his intuition that the killer is still out there. How these lives intertwine reveals a rich and startling story of parents and children and the pain they cause one another. "Gripping." CHICAGO SUN TIMES
This document is a compendium of scientifically valid and accepted methods that can be used to assess sediment quality and predict ecological impacts...the intent here is to provide the most useful overall measures or predictors of ecological impacts currently in use rather than procedures that may have limited application outside of a particular regulatory framework... parag The information provided in the compendium on the relative strengths and weaknesses of the different assessment methods can provide assistance in selecting the appropriate methods.
The aim of the American Psychiatric Association Practice Guideline series is to improve patient care. Guidelines provide a comprehensive synthesis of all available information relevant to the clinical topic. Practice guidelines can be vehicles for educating psychiatrists, other medical and mental health professionals, and the general public about appropriate and inappropriate treatments. The series also will identify those areas in which critical information is lacking and in which research could be expected to improve clinical decisions. The Practice Guidelines are also designed to help those charged with overseeing the utilization and reimbursement of psychiatric services to develop more scientifically based and clinically sensitive criteria.
Paul McCartney and John Lennon described him as the Beatles' "favorite group," he won Grammy awards, wrote and recorded hit songs, and yet no figure in popular music is as much of a paradox, or as underrated, as Harry Nilsson. In this first ever full-length biography, Alyn Shipton traces Nilsson's life from his Brooklyn childhood to his Los Angeles adolescence and his gradual emergence as a uniquely talented singer-songwriter. With interviews from friends, family, and associates, and material drawn from an unfinished autobiography, Shipton probes beneath the enigma to discover the real Harry Nilsson. A major celebrity at a time when huge concerts and festivals were becoming the norm, Nilsson shunned live performance. His venue was the studio, his stage the dubbing booth, his greatest triumphs masterful examples of studio craft. He was a gifted composer of songs for a wide variety of performers, including the Ronettes, the Yardbirds, and the Monkees, yet Nilsson's own biggest hits were almost all written by other songwriters. He won two Grammy awards, in 1969 for "Everybody's Talkin'" (the theme song for Midnight Cowboy), and in 1972 for "Without You," had two top ten singles, numerous album successes, and wrote a number of songs--"Coconut" and "Jump into the Fire," to name just two--that still sound remarkably fresh and original today. He was once described by his producer Richard Perry as "the finest white male singer on the planet," but near the end of his life, Nilsson's career was marked by voice-damaging substance abuse and the infamous deaths of both Keith Moon and Mama Cass in his London flat. Drawing on exclusive access to Nilsson's papers, Alyn Shipton's biography offers readers an intimate portrait of a man who has seemed both famous and unknowable--until now.
The puzzling adoption in 1930 of a deaf-mute method for teaching beginning reading to hearing children in America can only be understood when the long history of teaching beginning reading is known. The deaf-mute method adopted almost immediately after 1930 from the Atlantic to the Pacific Oceans and from Canada to Mexico was the "meaning" approach to teach the reading of alphabetic print instead of the "sound" approach. "Dick and Jane" primers and their clones, which teach beginning reading by meaning instead of by sound are, indeed, the disgraceful source for America's functional illiteracy problem. The history is an attempt to bring together most historical sources on those primers and on the long teaching of beginning reading itself so that functional illiteracy can be properly understood and successfully corrected.
This book investigates –s marking in English verbs, specifically its manifestations in main verbs, in the past tense of BE, and in existential constructions. It embraces the many ways in which –s marking varies across the English speaking world, and considers both how it arose in these places historically and the ways in which it has since developed. The authors propose a story which holistically accounts for these different manifestations of –s, drawing upon evidence from a wide range of subdisciplines in linguistics, including sociolinguistics, generative syntax, historical linguistics, dialectology, and discourse-pragmatics. This book will be of particular interest to students and scholars in these and related fields.
This book is bible for beginning radio professionals: the complete, definitive guide to the internal workings of radio stations and the radio industry. Not only will you begin understand how each job at a radio station is best performed, you will learn how it meshes with those of the rest of the radio station staff. If you are uncertain of your career goals, this book provides a solid foundation in who does what, when, and why. The Radio Station details all departments within a radio station. Topics explained include satellite radio, Web radio, AM stereo, cable and podcasting. Also, mergers and consolidation, future prospects, new digital technologies. This edition is loaded with new illustrations, feature boxes and quotes from industry pros, bringing it all together for the reader. Going strong after 20 years The Radio Station is now in its eighth edition and long considered the standard work on this audio medium. It remains a concise and candid guide to the internal workings of radio stations and the radio industry, explaining the functions performed successfully within every well-run station.