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The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Monographs in Modern Biology for Upper School and University Courses: Excitable Cells focuses on the fundamental nature of the signals carried in the nervous system, including nervous activity, synapses, and membrane permeability. The publication first elaborates on the elements of structure and function in the nervous system and resting nerve. Discussions focus on neuron, synapse, effect of changes in membrane permeability on membrane potential, recording nervous activity, movement of ions through solutions and membranes, and permeability of the resting membrane. The text then takes a look at the nerve impulse, including permeability changes associated with the nerve impulse, voltage clamp studies, and electrical model of the nerve membrane. The manuscript examines input signal and synapse. Topics include receptor discharge, generator potential, coding of the input message, frog neuromuscular junction, functional aspects of the vertebrate neuromuscular junction, nervous control of crustacean muscle, and central synapses. The publication is a dependable source material for biologists and readers interested in pursuing studies on excitable cells.
This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.
Here is a paperback edition of the standard reference first published in 1975.
A study of neuroprosthetics. It is broadly divided into three sections which address: neuroanatomy and neurophysiology, biomaterials and biocompatibility, stimulation and recording techniques; clinical applications of neuroprosthetics; and future developments.
This is an updated and abridged edition of the original volume published in 2004. Like its predecessor it is targeted for students of bioengineering, biomedical engineering, applied physiology, biological cybernetics and related fields; for engineers and scientists who have an interest in neuroprosthetics; and for medical practitioners using products of that field.The practice of neuroprosthetics requires a fundamental understanding of the anatomy and physiology of the nervous system, mathematical neurobiology, material science, electrochemistry, and electrophysiology. The text assumes some familiarity with basic anatomy, physiology, calculus, electrophysiology and bioinstrumentation, which typically are covered in undergraduate and first year graduate bioengineering curricula. These areas are also reviewed here, with the aim of consolidating principles fundamental to understanding the field. With that as background, the book then presents an overview of the field with detailed emphasis in selected areas of neural interfaces and neuroprostheses. The covered topics provide readers with sufficient information to understand the theory, rationale, design, and functioning of neuroprosthetic devices currently in clinical use and under development.The current volume is shorter than its predecessor. This has been achieved by reducing some of the repetition present in certain chapters of the earlier edition and eliminating a few chapters whose topics are now well covered in review literature readily available on the internet and elsewhere. Two chapters have been retained in their original versions to provide important background material, but the remaining chapters have either been revised by their original authors or replaced by new versions written by different authors. In addition new topics have been added to the section on existing systems.