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During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.
At present, computational methods have received considerable attention in economics and finance as an alternative to conventional analytical and numerical paradigms. This Special Issue brings together both theoretical and application-oriented contributions, with a focus on the use of computational techniques in finance and economics. Examined topics span on issues at the center of the literature debate, with an eye not only on technical and theoretical aspects but also very practical cases.
Includes established theories and cutting-edge developments. Presents the work of an international group of experts. Presents the nature, origin, implications, an future course of major unresolved issues in the area.
This book focuses on partitional clustering algorithms, which are commonly used in engineering and computer scientific applications. The goal of this volume is to summarize the state-of-the-art in partitional clustering. The book includes such topics as center-based clustering, competitive learning clustering and density-based clustering. Each chapter is contributed by a leading expert in the field.
As the title suggests, Isotope Effects in the Chemical, Geological and Bio Sciences deals with differences in the properties of isotopically substituted molecules, such as differences in the chemical and physical properties of water and the heavy waters. Since the various fields in which isotope effects are applied do not only share fundamental principles but also experimental techniques, this book includes a discussion of experimental apparatus and experimental techniques. Isotope Effects in the Chemical, Geological and Bio Sciences is an educational monograph addressed to graduate students and others undertaking isotope effect research. The fundamental principles needed to understand isotope effects are presented in appropriate detail. While it is true that these principles are more familiar to students of physical chemistry and some background in physical chemistry is recommended, the text provides enough detail to make the book an asset to students in organic and biochemistry, and geochemistry.
This third edition of the classic "how-to" guide incorporates recent changes in policies and procedures of the NIH, with particular emphasis on the role of the Internet in the research proposal process. Completely revised and updated, it reveals the secrets of success used by seasoned investigators, and directs the reader through the maze of NIH bureaucracies. In addition to providing a detailed overview of the entire review process, the book also includes hundreds of tips on how to enhance proposals, excerpts from real proposals, and extensive Internet references. This book is essential to all scientists involved in the grant writing process. Key Features: * Considers the reviewer's perspective * Detailed presentation of the review process * All sections of the R01 proposal are reviewed * Hundreds of tips to enhance proposals * Includes the many recent changes in NIH policies * Includes many excerpts from real proposals * Provides extensive Internet references Benefits: * Increased competitiveness * Better priority scores * Less chance of triage * Increased award rates * Uses the system to advantage * Reveals strategies used by the "old pros"
This practical full-color textbook introduces the fundamental physics behind radar measurements and their meteorological interpretation. A valuable resource for students, it includes problem sets, case studies, and supplementary electronic material. With a focus on operational and research applications, it is also a useful reference for researchers and professional meteorologists.
This volume contains 117 reviewed papers from over 30 countries, published in English, French and Spanish, which reflect both international dimension of FRIEND and the key challenges facing hydrologists in the 21st century.
Practical, real-world solutions are given to potential problems covering the entire system life cycle. This book describes how to map real-life systems (databases, data centers, and e-commerce applications) into analytic performance models. The authors elaborate upon these models and use them to help the reader better understand performance issues.
This book constitutes the thoroughly refereed post-conference proceedings of the first International Symposium on Intelligent Informatics (ISI'12) held in Chennai, India during August 4-5, 2012. The 54 revised papers presented were carefully reviewed and selected from 165 initial submissions. The papers are organized in topical sections on data mining, clustering and intelligent information systems, multi agent systems, pattern recognition, signal and image processing and, computer networks and distributed systems. The book is directed to the researchers and scientists engaged in various fields of intelligent informatics.