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There is little doubt that dissemination of disease by aircraft has occurred and will continue to occur. Epidemiology must keep pace with the ever-increasing problems of disease spread by this route. The control measures which have been instituted by WHO and the Pan-American Sanitary Bureau, along with the services of immunization procedures, modern methods of insect control and local public health measures, have been effective. Airline operators with international routes also have a great responsibility for maintaining precautionary measures in all aspects of public health and must provide competent medical and sanitary supervision of personnel and route facilities. Better control can be realized if universal cooperation is continued.