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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
This book constitutes the proceedings of the 26th International Working Conference on Requirements Engineering - Foundation for Software Quality, REFSQ 2020, held in Pisa, Italy, in March 2020. The 14 full papers and 7 short papers in this volume were carefully reviewed and selected from 84 submissions. The papers are organized in the following topical sections: requirements specification; requirements documentation; privacy and legal requirements; stakeholders feedback and training; agile methods and requirements comprehension; requirements modelling; requirements visualization.
This book constitutes the proceedings of the 27th International Working Conference on Requirements Engineering - Foundation for Software Quality, REFSQ 2021, which was due to be held in Essen, Germany, in April 2021. Due to the COVID-19 pandemic the conference was held virtually in April 2021. The special focus of this year`s REFSQ 2021 conference are contributions emphasizing the importance of human values, such as privacy and fairness, when designing software-intensive systems as well as the challenges that intelligent and autonomous systems pose due to the tight interplay with humans.
Geotechnical engineers are at work worldwide, contributing to sustainable living and to the creation of safe, economic and pleasant spaces to live, work and relax. With increased pressure on space and resources, particularly in cities, their expertise becomes ever more important. This book presents the proceedings of the 5th iYGEC, International Young Geotechnical Engineers' Conference, held at Marne-la-Vallée, France, from 31 August to 1 September 2013. It is also the second volume in the series Advances in Soil Mechanics and Geotechnical Engineering. The papers included here cover topics such as laboratory and field testing, geology and groundwater, earthworks, soil behavior, constitutive modeling, ground improvement, earthquake, retaining structures, foundations, slope stability, tunnels and observational methods. The iYGEC conference series brings together students and young people at the start of their career in the geotechnical professions to share their experience, and this book will be of interest to all those whose work involves soil mechanics and geotechnical engineering. The cover shows Dieppe harbour breakwater project, Louis-Alexandre de Cessart, 1776-1777. © École Nationale des Ponts et Chaussées.
Welcome to the proceedings of the Sixth International Conference on Management Science and Engineering Management (ICMSEM2012) held from November 11 to 14, 2012 at Quaid-i-Azam University, Islamabad, Pakistan and supported by Sichuan University (Chengdu, China), Quaid-i-Azam University (Islamabad, Pakistan) and The National Natural Science Foundation of China. The International Conference on Management Science and Engineering Management is the annual conference organized by the International Society of Management Science and Engineering Management. The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research results. The papers are classified into 8 sections: Computer and Networks, Information Technology, Decision Support System, Industrial Engineering, Supply Chain Management, Project Management, Manufacturing and Ecological Engineering. The key issues of the sixth ICMSEM cover various areas in MSEM, such as Decision Support System, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic models and Simulation, Heuristics Algorithms, Risk Control, and Carbon Credits.
Second International Conference on Chemical Engineering Education presents the situation in chemical engineering education in Germany, Hungary, Spain, Japan, and in the United States. This book depicts an awareness of the problems of professional education together with a wide spectrum of opinions on their solution. Organized into 39 chapters, this book begins with an overview of the actual situation of chemical engineering education program in Spain. This text then examines the detailed formalities of chemical engineering in secondary schools. Other chapters consider the change in chemical engineering education in Japan due to the change of chemical industries as well as by a great change of students' attitude. This book discusses as well the curriculum proposal for the education of undergraduate and graduate levels as well as foreign students' education. The final chapter reviews the European situation of chemical engineering education system. This book is a valuable resource for teachers and students of chemical engineering.
This book is the sixth volume of the proceedings of the 4th GeoShanghai International Conference that was held on May 27 - 30, 2018. This volume, entitled “Advances in Soil Dynamics and Foundation Engineering”, covers the recent advances and technologies in soil dynamics and foundation engineering. These papers are grouped into four categories: (1) soil dynamics and earthquake engineering, (2) deep excavations and retaining structures, (3) shafts and deep foundations, and (4) offshore geotechnics. It presents the state-of-the-art theories, experiments, methodologies and findings in the related areas. The book may benefit researchers and scientists from the academic fields of soil dynamics and earthquake engineering, geotechnical engineering, geoenvironmental engineering, transportation engineering, geology, mining and energy, as well as practical engineers from the industry. Each of the papers included in this book received at least two positive peer reviews. The editors would like to express their sincerest appreciation to all of the anonymous reviewers all over the world, for their diligent work.
This book constitutes the proceedings of the First International Conference on Emerging Trends in Engineering (ICETE), held at University College of Engineering and organised by the Alumni Association, University College of Engineering, Osmania University, in Hyderabad, India on 22–23 March 2019. The proceedings of the ICETE are published in three volumes, covering seven areas: Biomedical, Civil, Computer Science, Electrical & Electronics, Electronics & Communication, Mechanical, and Mining Engineering. The 215 peer-reviewed papers from around the globe present the latest state-of-the-art research, and are useful to postgraduate students, researchers, academics and industry engineers working in the respective fields. This volume presents state-of-the-art, technical contributions in the areas of civil, mechanical and mining engineering, discussing sustainable developments in fields such as water resource engineering, structural engineering, geotechnical and transportation engineering, mining engineering, production and industrial engineering, thermal engineering, design engineering, and production engineering.